DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seo, Taegun | ko |
dc.contributor.author | Park, Junsoo | ko |
dc.contributor.author | Lim, Chunghun | ko |
dc.contributor.author | Choe, Joonho | ko |
dc.date.accessioned | 2013-03-06T03:19:03Z | - |
dc.date.available | 2013-03-06T03:19:03Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2004-08 | - |
dc.identifier.citation | ONCOGENE, v.23, no.36, pp.6146 - 6155 | - |
dc.identifier.issn | 0950-9232 | - |
dc.identifier.uri | http://hdl.handle.net/10203/85667 | - |
dc.description.abstract | Nuclear factor-kappaB (NF-kappaB) is a transcription factor that plays an important role in the immune system and cell death. Many viral proteins modulate NF-kappaB to escape host immune surveillance, promote cell survival, and enhance viral replication. In the present study, we show that NF-kappaB activity is downmodulated by viral interferon regulatory factor 3 (vIRF3), which is encoded by Kaposi's sarcoma-associated herpesvirus open-reading frame K10.5. vIRF3 repressed NF-kappaB-dependent transcription in a dose-dependent manner and inhibited the activation of NF-kappaB induced by tumor necrosis factor (TNF)-alpha. In vivo studies showed vIRF3 inhibited IkappaB kinase beta (IKKbeta) activity, but not IKKalpha activity, resulting in reduced IkappaB phosphorylation. Immunofluorescence assays showed that vIRF3 interfered with nuclear translocation of NF-kappaB. In addition, consistent with the inhibition of NF-kappaB activity, vIRF3 sensitized cells to TNF-alpha-induced apoptosis. While vIRF3 interacts with IKKbeta in vitro and in 293T cells, we were unable to demonstrate vIRF3-IKKbeta interaction in BCBL-1 cells. Our results indicate that vIRF3 can regulate the host immune system and apoptosis via inhibition of NF-kappaB activity. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Inhibition of nuclear factor kappa B activity by viral interferon regulatory factor 3 of Kaposis sarcoma-associated herpesvirus | - |
dc.type | Article | - |
dc.identifier.wosid | 000223261000014 | - |
dc.identifier.scopusid | 2-s2.0-4444279888 | - |
dc.type.rims | ART | - |
dc.citation.volume | 23 | - |
dc.citation.issue | 36 | - |
dc.citation.beginningpage | 6146 | - |
dc.citation.endingpage | 6155 | - |
dc.citation.publicationname | ONCOGENE | - |
dc.identifier.doi | 10.1038/sj.onc.1207807 | - |
dc.contributor.localauthor | Lim, Chunghun | - |
dc.contributor.localauthor | Choe, Joonho | - |
dc.contributor.nonIdAuthor | Seo, Taegun | - |
dc.contributor.nonIdAuthor | Park, Junsoo | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | KSHV | - |
dc.subject.keywordAuthor | VIRF3 | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | IKK | - |
dc.subject.keywordPlus | INDUCED CELL-DEATH | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | KINASE COMPLEX | - |
dc.subject.keywordPlus | IKK-ALPHA | - |
dc.subject.keywordPlus | DNA-SEQUENCES | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR | - |
dc.subject.keywordPlus | MICE LACKING | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | BETA | - |
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