Dephosphorylation of p53 during cell death by N-alpha-tosyl-L-phenylalanyl chloromethyl ketone

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dc.contributor.authorKim, Kko
dc.contributor.authorChoi, KHko
dc.contributor.authorFu, YMko
dc.contributor.authorMeadows, GGko
dc.contributor.authorJoe, Cheol Oko
dc.date.accessioned2013-03-06T03:07:39Z-
dc.date.available2013-03-06T03:07:39Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2003-07-
dc.identifier.citationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.306, no.4, pp.954 - 958-
dc.identifier.issn0006-291X-
dc.identifier.urihttp://hdl.handle.net/10203/85634-
dc.description.abstractThe apoptotic function of N-alpha-tosyl-L-phenylalanyl chloromethyl ketone (TPCK) was investigated in cultured human colorectal carcinoma cells (HCT116). TPCK-induced apoptosis was shown to be p53-dependent in HCT116 cells during the early stage of incubation. The function of p53 was required for TPCK-induced activation of caspase-3 and caspase-7. TPCK promoted dephosphorylation of p53 on serine residues at 6, 9, 46, 376, and 378 in parallel with the activation of p53 transcriptional activity. HCT116 p53-/- cells expressing p53 mutant, in which serine residues at 6, 9, 46, 376, and 378 were replaced by aspartic acids, were resistant to TPCK-induced apoptosis suggesting the requirement of dephosphorylation of p53 on serine residues during TPCK-induced apoptosis. (C) 2003 Elsevier Science (USA). All rights reserved.-
dc.languageEnglish-
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE-
dc.subjectDAMAGE-INDUCED PHOSPHORYLATION-
dc.subjectTUMOR-SUPPRESSOR PROTEIN-
dc.subjectDNA-BINDING FUNCTION-
dc.subjectMURINE B-CELLS-
dc.subjectTERMINAL SITES-
dc.subjectAPOPTOSIS-
dc.subjectINHIBITION-
dc.subject14-3-3-PROTEINS-
dc.subjectASSOCIATION-
dc.subjectACTIVATION-
dc.titleDephosphorylation of p53 during cell death by N-alpha-tosyl-L-phenylalanyl chloromethyl ketone-
dc.typeArticle-
dc.identifier.wosid000183992400024-
dc.identifier.scopusid2-s2.0-0038095289-
dc.type.rimsART-
dc.citation.volume306-
dc.citation.issue4-
dc.citation.beginningpage954-
dc.citation.endingpage958-
dc.citation.publicationnameBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.contributor.localauthorJoe, Cheol O-
dc.contributor.nonIdAuthorKim, K-
dc.contributor.nonIdAuthorChoi, KH-
dc.contributor.nonIdAuthorFu, YM-
dc.contributor.nonIdAuthorMeadows, GG-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorTPCK-
dc.subject.keywordAuthorp53-
dc.subject.keywordAuthordephosphorylation-
dc.subject.keywordAuthorapoptosis-
dc.subject.keywordAuthorcaspase-
dc.subject.keywordPlusDAMAGE-INDUCED PHOSPHORYLATION-
dc.subject.keywordPlusTUMOR-SUPPRESSOR PROTEIN-
dc.subject.keywordPlusDNA-BINDING FUNCTION-
dc.subject.keywordPlusMURINE B-CELLS-
dc.subject.keywordPlusTERMINAL SITES-
dc.subject.keywordPlusAPOPTOSIS-
dc.subject.keywordPlusINHIBITION-
dc.subject.keywordPlus14-3-3-PROTEINS-
dc.subject.keywordPlusASSOCIATION-
dc.subject.keywordPlusACTIVATION-
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