DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, K | ko |
dc.contributor.author | Choi, KH | ko |
dc.contributor.author | Fu, YM | ko |
dc.contributor.author | Meadows, GG | ko |
dc.contributor.author | Joe, Cheol O | ko |
dc.date.accessioned | 2013-03-06T03:07:39Z | - |
dc.date.available | 2013-03-06T03:07:39Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2003-07 | - |
dc.identifier.citation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.306, no.4, pp.954 - 958 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | http://hdl.handle.net/10203/85634 | - |
dc.description.abstract | The apoptotic function of N-alpha-tosyl-L-phenylalanyl chloromethyl ketone (TPCK) was investigated in cultured human colorectal carcinoma cells (HCT116). TPCK-induced apoptosis was shown to be p53-dependent in HCT116 cells during the early stage of incubation. The function of p53 was required for TPCK-induced activation of caspase-3 and caspase-7. TPCK promoted dephosphorylation of p53 on serine residues at 6, 9, 46, 376, and 378 in parallel with the activation of p53 transcriptional activity. HCT116 p53-/- cells expressing p53 mutant, in which serine residues at 6, 9, 46, 376, and 378 were replaced by aspartic acids, were resistant to TPCK-induced apoptosis suggesting the requirement of dephosphorylation of p53 on serine residues during TPCK-induced apoptosis. (C) 2003 Elsevier Science (USA). All rights reserved. | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | DAMAGE-INDUCED PHOSPHORYLATION | - |
dc.subject | TUMOR-SUPPRESSOR PROTEIN | - |
dc.subject | DNA-BINDING FUNCTION | - |
dc.subject | MURINE B-CELLS | - |
dc.subject | TERMINAL SITES | - |
dc.subject | APOPTOSIS | - |
dc.subject | INHIBITION | - |
dc.subject | 14-3-3-PROTEINS | - |
dc.subject | ASSOCIATION | - |
dc.subject | ACTIVATION | - |
dc.title | Dephosphorylation of p53 during cell death by N-alpha-tosyl-L-phenylalanyl chloromethyl ketone | - |
dc.type | Article | - |
dc.identifier.wosid | 000183992400024 | - |
dc.identifier.scopusid | 2-s2.0-0038095289 | - |
dc.type.rims | ART | - |
dc.citation.volume | 306 | - |
dc.citation.issue | 4 | - |
dc.citation.beginningpage | 954 | - |
dc.citation.endingpage | 958 | - |
dc.citation.publicationname | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.contributor.localauthor | Joe, Cheol O | - |
dc.contributor.nonIdAuthor | Kim, K | - |
dc.contributor.nonIdAuthor | Choi, KH | - |
dc.contributor.nonIdAuthor | Fu, YM | - |
dc.contributor.nonIdAuthor | Meadows, GG | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | TPCK | - |
dc.subject.keywordAuthor | p53 | - |
dc.subject.keywordAuthor | dephosphorylation | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | caspase | - |
dc.subject.keywordPlus | DAMAGE-INDUCED PHOSPHORYLATION | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR PROTEIN | - |
dc.subject.keywordPlus | DNA-BINDING FUNCTION | - |
dc.subject.keywordPlus | MURINE B-CELLS | - |
dc.subject.keywordPlus | TERMINAL SITES | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | 14-3-3-PROTEINS | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
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