DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Injune | ko |
dc.contributor.author | Moon SO | ko |
dc.contributor.author | Park SK | ko |
dc.contributor.author | Chae SW | ko |
dc.contributor.author | Koh, Gou Young | ko |
dc.date.accessioned | 2013-03-06T02:55:27Z | - |
dc.date.available | 2013-03-06T02:55:27Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2001-09 | - |
dc.identifier.citation | CIRCULATION RESEARCH, v.89, no.6, pp.477 - 479 | - |
dc.identifier.issn | 0009-7330 | - |
dc.identifier.uri | http://hdl.handle.net/10203/85607 | - |
dc.description.abstract | Vascular endothelial growth factor (VEGF) and angiopoietin-1 (Ang1) are potent vasculogenic and angiogenic factors that hold promise as a means to produce therapeutic vascularization and angiogenesis. However, VEGF also acts as a proinflammatory cytokine by inducing adhesion molecules that bind leukocytes; to endothelial cells, an initial and essential step toward inflammation. In the present study, we used human umbilical vascular endothelial cells (HUVECs) to examine the effect of Ang1 on VEGF-induced expression of three adhesion molecules: intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin. Interestingly, Ana1 suppressed VEGF-induced expression of these adhesion molecules. Furthermore, Angl reduced VEGF-induced leukocyte adhesion to HUVECs. These results demonstrate that Ang1 counteracts VEGF-induced inflammation by reducing VEGF-induced endothetial adhesiveness. | - |
dc.language | English | - |
dc.publisher | LIPPINCOTT WILLIAMS WILKINS | - |
dc.subject | PATHWAY | - |
dc.subject | MICE | - |
dc.title | Angiopoietin-1 Reduces VEGF-Stimulated Leukocyte Adhesion to Endothelial Cells by Reducing ICAM-1, VCAM-1, and E-Selectin Expression. | - |
dc.type | Article | - |
dc.identifier.wosid | 000171016000005 | - |
dc.identifier.scopusid | 2-s2.0-0035860845 | - |
dc.type.rims | ART | - |
dc.citation.volume | 89 | - |
dc.citation.issue | 6 | - |
dc.citation.beginningpage | 477 | - |
dc.citation.endingpage | 479 | - |
dc.citation.publicationname | CIRCULATION RESEARCH | - |
dc.identifier.doi | 10.1161/hh1801.097034 | - |
dc.contributor.localauthor | Kim, Injune | - |
dc.contributor.localauthor | Koh, Gou Young | - |
dc.contributor.nonIdAuthor | Moon SO | - |
dc.contributor.nonIdAuthor | Park SK | - |
dc.contributor.nonIdAuthor | Chae SW | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | vascular endothelial growth factor | - |
dc.subject.keywordAuthor | angiopoietin | - |
dc.subject.keywordAuthor | adhesion | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | MICE | - |
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