DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Injune | ko |
dc.contributor.author | Oh, Jong-Lark | ko |
dc.contributor.author | Ryu, Young Shin | ko |
dc.contributor.author | So, June-No | ko |
dc.contributor.author | Sessa, William C. | ko |
dc.contributor.author | Walsh, Kenneth | ko |
dc.contributor.author | Koh, Gou Young | ko |
dc.date.accessioned | 2013-03-05T04:40:18Z | - |
dc.date.available | 2013-03-05T04:40:18Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2002-01 | - |
dc.identifier.citation | FASEB JOURNAL, v.16, no.1, pp.126 - 126 | - |
dc.identifier.issn | 0892-6638 | - |
dc.identifier.uri | http://hdl.handle.net/10203/85526 | - |
dc.description.abstract | Normally, tissue factor (TF) is not expressed on the surface of endothelial cells, but its expression can be induced by vascular endothelial growth factor (VEGF) and tumor necrosis factor (TNF)-alpha. However, the signaling pathway(s) affecting this induction is unknown. Using human umbilical vein endothelial cells, we found that inhibitors of guanine-cytosine-rich DNA binding protein and nuclear factor (NF)-kappaB suppressed VEGF- and TNF-alpha -induced expression and activity of TF. However, unexpectedly, phosphatidylinositol (PI) 3'-kinase inhibitor enhanced the VEGF- and TNF-alpha -induced expression and activity of TF. Angiopoietin-1 (Ang1), a strong activator of intracellular PI 3'-kinase/Akt, inhibited the induction of TF by VEGF and TNF-alpha, whereas Ang1 itself did not produce any significant effect on TF. Selective activation (or inactivation) of PI 3'-kinase/Akt by using adenoviral transfer reduced (or enhanced) TNF-alpha -induced expression of TF mRNA and protein, regardless of Ang1 treatment. From these results, we conclude that Ang1 inhibits the up-regulation of TF expression, possibly through activation of PI 3'-kinase/Akt in endothelial cells. Ang1 may be useful as an inhibitor of VEGF- and TNF-alpha -induced coagulation, inflammation, and cancer progression. | - |
dc.language | English | - |
dc.publisher | FEDERATION AMER SOC EXP BIOL | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | TUMOR-NECROSIS-FACTOR | - |
dc.subject | SIGNAL-TRANSDUCTION PATHWAY | - |
dc.subject | BLOOD-VESSEL DEVELOPMENT | - |
dc.subject | SERINE-THREONINE KINASE | - |
dc.subject | GROWTH-FACTOR | - |
dc.subject | OVEREXPRESSING ANGIOPOIETIN-1 | - |
dc.subject | VASCULAR-PERMEABILITY | - |
dc.subject | TIE2 RECEPTOR | - |
dc.subject | FACTOR GENE | - |
dc.title | Angiopoietin-1 negatively regulates expression and activity of tissue factor in endothelial cells | - |
dc.type | Article | - |
dc.identifier.wosid | 000172420500027 | - |
dc.identifier.scopusid | 2-s2.0-0036368598 | - |
dc.type.rims | ART | - |
dc.citation.volume | 16 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 126 | - |
dc.citation.endingpage | 126 | - |
dc.citation.publicationname | FASEB JOURNAL | - |
dc.identifier.doi | 10.1096/fj.01-0556fje | - |
dc.contributor.localauthor | Kim, Injune | - |
dc.contributor.localauthor | Koh, Gou Young | - |
dc.contributor.nonIdAuthor | Oh, Jong-Lark | - |
dc.contributor.nonIdAuthor | Ryu, Young Shin | - |
dc.contributor.nonIdAuthor | So, June-No | - |
dc.contributor.nonIdAuthor | Sessa, William C. | - |
dc.contributor.nonIdAuthor | Walsh, Kenneth | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | vascular endothelial growth factor | - |
dc.subject.keywordAuthor | TNF-alpha | - |
dc.subject.keywordAuthor | Akt | - |
dc.subject.keywordAuthor | phosphatidylinositol 3 &apos | - |
dc.subject.keywordAuthor | -kinase | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | TUMOR-NECROSIS-FACTOR | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION PATHWAY | - |
dc.subject.keywordPlus | BLOOD-VESSEL DEVELOPMENT | - |
dc.subject.keywordPlus | SERINE-THREONINE KINASE | - |
dc.subject.keywordPlus | GROWTH-FACTOR | - |
dc.subject.keywordPlus | OVEREXPRESSING ANGIOPOIETIN-1 | - |
dc.subject.keywordPlus | VASCULAR-PERMEABILITY | - |
dc.subject.keywordPlus | TIE2 RECEPTOR | - |
dc.subject.keywordPlus | FACTOR GENE | - |
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