DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, CH | ko |
dc.contributor.author | Kammerer, RA | ko |
dc.contributor.author | Lee, HJ | ko |
dc.contributor.author | Steinmetz, MO | ko |
dc.contributor.author | Ryu, YS | ko |
dc.contributor.author | Lee, SH | ko |
dc.contributor.author | Yasunaga, K | ko |
dc.contributor.author | Kim, KT | ko |
dc.contributor.author | Kim, Injune | ko |
dc.contributor.author | Choi, HH | ko |
dc.contributor.author | Kim, W | ko |
dc.contributor.author | Kim, SH | ko |
dc.contributor.author | Park, SK | ko |
dc.contributor.author | Lee, Gyun-Min | ko |
dc.contributor.author | Koh, Gou-Young | ko |
dc.date.accessioned | 2013-03-05T03:53:02Z | - |
dc.date.available | 2013-03-05T03:53:02Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2004-04 | - |
dc.identifier.citation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.101, no.15, pp.5547 - 5552 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/10203/85358 | - |
dc.description.abstract | Angiopoietin-1 (Ang1) has potential therapeutic applications in inducing angiogenesis, enhancing endothelial cell survival, and preventing vascular leakage. However, production of Ang1 is hindered by aggregation and insolubility resulting from disulfide-linked higher-order structures. Here, by replacing the N-terminal portion of Ang1 with the short coiled-coil domain of cartilage oligomeric matrix protein (COMP), we have generated a soluble, stable, and potent Ang1 variant, COMP-Ang1. This variant is more potent than native Ang1 in phosphorylating the tyrosine kinase with Ig and epidermal growth factor homology domain 2 (Tie2) receptor and Akt in primary cultured endothelial cells, enhancing angiogenesis in vitro and increasing adult angiogenesis in vivo. Thus, COMP-Ang1 is an effective alternative to native Ang1 for therapeutic angiogenesis in vivo. | - |
dc.language | English | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.subject | COILED-COIL | - |
dc.subject | TIE2 RECEPTOR | - |
dc.subject | OVEREXPRESSING ANGIOPOIETIN-1 | - |
dc.subject | POSTNATAL NEOVASCULARIZATION | - |
dc.subject | ENDOTHELIAL-CELLS | - |
dc.subject | INDUCED APOPTOSIS | - |
dc.subject | LIGAND | - |
dc.subject | GROWTH | - |
dc.subject | VASCULARIZATION | - |
dc.subject | ACTIVATION | - |
dc.title | COMP-Ang1: A designed angiopoietin-1 variant with nonleaky angiogenic activity | - |
dc.type | Article | - |
dc.identifier.wosid | 000220861500046 | - |
dc.identifier.scopusid | 2-s2.0-11144357304 | - |
dc.type.rims | ART | - |
dc.citation.volume | 101 | - |
dc.citation.issue | 15 | - |
dc.citation.beginningpage | 5547 | - |
dc.citation.endingpage | 5552 | - |
dc.citation.publicationname | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.identifier.doi | 10.1073/pnas.0307574101 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Kim, Injune | - |
dc.contributor.localauthor | Lee, Gyun-Min | - |
dc.contributor.localauthor | Koh, Gou-Young | - |
dc.contributor.nonIdAuthor | Cho, CH | - |
dc.contributor.nonIdAuthor | Kammerer, RA | - |
dc.contributor.nonIdAuthor | Lee, HJ | - |
dc.contributor.nonIdAuthor | Steinmetz, MO | - |
dc.contributor.nonIdAuthor | Ryu, YS | - |
dc.contributor.nonIdAuthor | Lee, SH | - |
dc.contributor.nonIdAuthor | Yasunaga, K | - |
dc.contributor.nonIdAuthor | Kim, KT | - |
dc.contributor.nonIdAuthor | Choi, HH | - |
dc.contributor.nonIdAuthor | Kim, W | - |
dc.contributor.nonIdAuthor | Kim, SH | - |
dc.contributor.nonIdAuthor | Park, SK | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | COILED-COIL | - |
dc.subject.keywordPlus | TIE2 RECEPTOR | - |
dc.subject.keywordPlus | OVEREXPRESSING ANGIOPOIETIN-1 | - |
dc.subject.keywordPlus | POSTNATAL NEOVASCULARIZATION | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | LIGAND | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | VASCULARIZATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
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