Intracellular drug delivery using poly(D,L-lactide-co-glycolide) nanoparticles derivatized with a peptide from a transcriptional activator protein of HIV-1

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Biodegradable poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles were derivatized with Tat(49-57) peptide, which is the protein transduction domain from the transcriptional activator Tat protein of human immunodeficiency virus type-1 (HIV-1). The Tat(49-57) peptide-modified PLGA nanoparticles, with a mean diameter of ca. 238 nm, was effectively adsorbed on to the membrane of HaCaT cells and delivered into the nuclei without cytotoxicity.
Publisher
SPRINGER
Issue Date
2002-12
Language
English
Article Type
Article
Keywords

TOXICITY; THERAPY

Citation

BIOTECHNOLOGY LETTERS, v.24, no.24, pp.2093 - 2098

ISSN
0141-5492
DOI
10.1023/A:1021373731787
URI
http://hdl.handle.net/10203/84107
Appears in Collection
MS-Journal Papers(저널논문)
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