DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cherny, RA | ko |
dc.contributor.author | Atwood, CS | ko |
dc.contributor.author | Xilinas, ME | ko |
dc.contributor.author | Gray, DN | ko |
dc.contributor.author | Jones, Walton D | ko |
dc.contributor.author | McLean, CA | ko |
dc.contributor.author | Barnham, KJ | ko |
dc.contributor.author | Volitakis, I | ko |
dc.contributor.author | Fraser, FW | ko |
dc.contributor.author | Kim, YS | ko |
dc.contributor.author | Huang, XD | ko |
dc.contributor.author | Goldstein, LE | ko |
dc.contributor.author | Moir, RD | ko |
dc.contributor.author | Lim, JT | ko |
dc.contributor.author | Beyreuther, K | ko |
dc.contributor.author | Zheng, H | ko |
dc.contributor.author | Tanzi, RE | ko |
dc.contributor.author | Masters, CL | ko |
dc.contributor.author | Bush, AI | ko |
dc.date.accessioned | 2013-03-04T18:22:34Z | - |
dc.date.available | 2013-03-04T18:22:34Z | - |
dc.date.created | 2012-05-06 | - |
dc.date.created | 2012-05-06 | - |
dc.date.issued | 2001-06 | - |
dc.identifier.citation | NEURON, v.30, no.3, pp.665 - 676 | - |
dc.identifier.issn | 0896-6273 | - |
dc.identifier.uri | http://hdl.handle.net/10203/83617 | - |
dc.description.abstract | Inhibition of neocortical beta -amyloid (A beta) accumulation may be essential in an effective therapeutic intervention for Alzheimer's disease (AD). Cu and Zn are enriched in A beta deposits in AD, which are solubilized by Cu/Zn-selective chelators in vitro. Here we report a 49% decrease in brain A beta deposition (-375 mug/g wet weight, p = 0.0001) in a blinded study of APP2576 transgenic mice treated orally for 9 weeks with clioquinol, an antibiotic and bioavailable Cu/Zn chelator. This was accompanied by a modest increase in soluble A beta (1.45% of total cerebral A beta); APP, synaptophysin, and GFAP levels were unaffected. General health and body weight parameters were significantly more stable in the treated animals. These results support targeting the interactions of Cu and Zn with A beta as a novel therapy for the prevention and treatment of AD. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.subject | A-BETA | - |
dc.subject | MOUSE MODEL | - |
dc.subject | FREE-RADICALS | - |
dc.subject | PEPTIDE | - |
dc.subject | PLAQUES | - |
dc.subject | PROTEIN | - |
dc.subject | AGGREGATION | - |
dc.subject | CLIOQUINOL | - |
dc.subject | PATHOLOGY | - |
dc.subject | BRAINS | - |
dc.title | Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice | - |
dc.type | Article | - |
dc.identifier.wosid | 000169508900008 | - |
dc.identifier.scopusid | 2-s2.0-0034964390 | - |
dc.type.rims | ART | - |
dc.citation.volume | 30 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 665 | - |
dc.citation.endingpage | 676 | - |
dc.citation.publicationname | NEURON | - |
dc.identifier.doi | 10.1016/S0896-6273(01)00317-8 | - |
dc.contributor.localauthor | Jones, Walton D | - |
dc.contributor.nonIdAuthor | Cherny, RA | - |
dc.contributor.nonIdAuthor | Atwood, CS | - |
dc.contributor.nonIdAuthor | Xilinas, ME | - |
dc.contributor.nonIdAuthor | Gray, DN | - |
dc.contributor.nonIdAuthor | McLean, CA | - |
dc.contributor.nonIdAuthor | Barnham, KJ | - |
dc.contributor.nonIdAuthor | Volitakis, I | - |
dc.contributor.nonIdAuthor | Fraser, FW | - |
dc.contributor.nonIdAuthor | Kim, YS | - |
dc.contributor.nonIdAuthor | Huang, XD | - |
dc.contributor.nonIdAuthor | Goldstein, LE | - |
dc.contributor.nonIdAuthor | Moir, RD | - |
dc.contributor.nonIdAuthor | Lim, JT | - |
dc.contributor.nonIdAuthor | Beyreuther, K | - |
dc.contributor.nonIdAuthor | Zheng, H | - |
dc.contributor.nonIdAuthor | Tanzi, RE | - |
dc.contributor.nonIdAuthor | Masters, CL | - |
dc.contributor.nonIdAuthor | Bush, AI | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | A-BETA | - |
dc.subject.keywordPlus | MOUSE MODEL | - |
dc.subject.keywordPlus | FREE-RADICALS | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.subject.keywordPlus | PLAQUES | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | AGGREGATION | - |
dc.subject.keywordPlus | CLIOQUINOL | - |
dc.subject.keywordPlus | PATHOLOGY | - |
dc.subject.keywordPlus | BRAINS | - |
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