DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Daeyoup | ko |
dc.contributor.author | Lim, Chunghun | ko |
dc.contributor.author | Seo, Taegun | ko |
dc.contributor.author | Kwon, Hyockman | ko |
dc.contributor.author | Min, Hyesun | ko |
dc.contributor.author | Choe, Joonho | ko |
dc.date.accessioned | 2013-03-04T15:32:27Z | - |
dc.date.available | 2013-03-04T15:32:27Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2002-12 | - |
dc.identifier.citation | JOURNAL OF BIOLOGICAL CHEMISTRY, v.277, no.50, pp.48842 - 48848 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | http://hdl.handle.net/10203/83081 | - |
dc.description.abstract | BRG-1, a component of the human SWI/SNF complex, either activates or represses cellular promoters by modulating chromatin structure via the formation of a multiple polypeptide complex. Human papillomavirus E7 binds and destabilizes pRb, resulting in the blockage of G(1) arrest in the cell cycle. We show here that the high-risk human papillomavirus E7 protein group binds BRG-1 and modulates repression of the c-fos promoter mediated by this protein. In addition, both wild-type and Rb binding-defective E7 proteins abolish flat cell formation by BRG-1 in SW13 cells, whereas E7 COOH-terminal mutants do not affect this process. BRG-1-triggered repression of the c-fos promoter is sensitive to trichostatin A. We further establish that BRG-1 contains an activation domain and a trichostatin A-sensitive repression domain. These results collectively suggest that the viral oncogene E7 targets both pRb and BRG-1 via protein-protein interactions, resulting in the deregulation of host cell cycle control. | - |
dc.language | English | - |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | - |
dc.title | The viral oncogene human papillomavirus E7 deregulates transcriptional silencing by Brm-related gene 1 via molecular interactions | - |
dc.type | Article | - |
dc.identifier.wosid | 000179789600113 | - |
dc.identifier.scopusid | 2-s2.0-0037073682 | - |
dc.type.rims | ART | - |
dc.citation.volume | 277 | - |
dc.citation.issue | 50 | - |
dc.citation.beginningpage | 48842 | - |
dc.citation.endingpage | 48848 | - |
dc.citation.publicationname | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.identifier.doi | 10.1074/jbc.M203583200 | - |
dc.contributor.localauthor | Lee, Daeyoup | - |
dc.contributor.localauthor | Lim, Chunghun | - |
dc.contributor.localauthor | Choe, Joonho | - |
dc.contributor.nonIdAuthor | Seo, Taegun | - |
dc.contributor.nonIdAuthor | Kwon, Hyockman | - |
dc.contributor.nonIdAuthor | Min, Hyesun | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | RETINOBLASTOMA TUMOR-SUPPRESSOR | - |
dc.subject.keywordPlus | MAMMALIAN SWI/SNF COMPLEXES | - |
dc.subject.keywordPlus | CELL-CYCLE ARREST | - |
dc.subject.keywordPlus | C-FOS GENE | - |
dc.subject.keywordPlus | TYPE-16 E7 | - |
dc.subject.keywordPlus | HISTONE ACETYLATION | - |
dc.subject.keywordPlus | SACCHAROMYCES-CEREVISIAE | - |
dc.subject.keywordPlus | TRANSFORMING ACTIVITY | - |
dc.subject.keywordPlus | MUTATIONAL ANALYSIS | - |
dc.subject.keywordPlus | HUMAN KERATINOCYTES | - |
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