DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Seok-Ho | ko |
dc.contributor.author | Kang, Yong-Kook | ko |
dc.contributor.author | Koo, Deog-Bon | ko |
dc.contributor.author | Kang, Man-Jong | ko |
dc.contributor.author | Moon, Seung-Ju | ko |
dc.contributor.author | Lee, Kyung-Kwang | ko |
dc.contributor.author | Han, Yong Mahn | ko |
dc.date.accessioned | 2013-03-04T15:09:13Z | - |
dc.date.available | 2013-03-04T15:09:13Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2004-11 | - |
dc.identifier.citation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.324, no.1, pp.58 - 63 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | http://hdl.handle.net/10203/83028 | - |
dc.description.abstract | Genome-wide changes of DNA methylation by active and passive demethylation processes are typical features during preimplantation development. Here we provide an insight that epigenetic reprogramming of DNA methylation is regulated in a region-specific manner, not a genome-wide fashion. To address this hypothesis, methylation states of three repetitive genomic regions were monitored at various developmental stages in the mouse embryos. Active demethylation was not observed in the IAP sequences whereas methylation reprogramming of the satellite sequences was regulated only by the active mechanism. Etn elements were actively demethylated after fertilization, passively demethylated by the 8-cell stage, and de novo methylated at the morular and blastocyst stages, showing dynamic epigenetic changes. Thus, our findings suggest that the specific genomic regions or sequences may spatially/temporally have their unique characteristics in the reprogramming of the DNA methylation during preimplantation development. (C) 2004 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | GERM-CELLS | - |
dc.subject | EPIGENETIC INHERITANCE | - |
dc.subject | MAMMALIAN DEVELOPMENT | - |
dc.subject | PATERNAL GENOME | - |
dc.subject | CLONED EMBRYOS | - |
dc.subject | DEMETHYLATION | - |
dc.subject | METHYLTRANSFERASE | - |
dc.subject | GENE | - |
dc.subject | PATTERNS | - |
dc.title | Differential DNA methylation reprogramming of various repetitive sequences in mouse preimplantation embryos | - |
dc.type | Article | - |
dc.identifier.wosid | 000224595300010 | - |
dc.identifier.scopusid | 2-s2.0-4744348332 | - |
dc.type.rims | ART | - |
dc.citation.volume | 324 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 58 | - |
dc.citation.endingpage | 63 | - |
dc.citation.publicationname | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.identifier.doi | 10.1016/j.bbrc.2004.09.023 | - |
dc.contributor.localauthor | Han, Yong Mahn | - |
dc.contributor.nonIdAuthor | Kim, Seok-Ho | - |
dc.contributor.nonIdAuthor | Kang, Yong-Kook | - |
dc.contributor.nonIdAuthor | Koo, Deog-Bon | - |
dc.contributor.nonIdAuthor | Kang, Man-Jong | - |
dc.contributor.nonIdAuthor | Moon, Seung-Ju | - |
dc.contributor.nonIdAuthor | Lee, Kyung-Kwang | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | DNA methylation | - |
dc.subject.keywordAuthor | repetitive sequences | - |
dc.subject.keywordAuthor | epigenetic reprogramming | - |
dc.subject.keywordAuthor | preimplantation embryo | - |
dc.subject.keywordAuthor | mouse | - |
dc.subject.keywordPlus | GERM-CELLS | - |
dc.subject.keywordPlus | EPIGENETIC INHERITANCE | - |
dc.subject.keywordPlus | MAMMALIAN DEVELOPMENT | - |
dc.subject.keywordPlus | PATERNAL GENOME | - |
dc.subject.keywordPlus | CLONED EMBRYOS | - |
dc.subject.keywordPlus | DEMETHYLATION | - |
dc.subject.keywordPlus | METHYLTRANSFERASE | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | PATTERNS | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.