DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hannan, Anthony J. | ko |
dc.contributor.author | Blakemore, Colin | ko |
dc.contributor.author | Katsnelson, Alla | ko |
dc.contributor.author | Vitalis, Tania | ko |
dc.contributor.author | Huber, Kimberly M. | ko |
dc.contributor.author | Bear, Mark | ko |
dc.contributor.author | Roder, John | ko |
dc.contributor.author | Kim, Daesoo | ko |
dc.contributor.author | Shin, Hee-Sup | ko |
dc.contributor.author | Kind, Peter C. | ko |
dc.date.accessioned | 2013-03-04T14:36:00Z | - |
dc.date.available | 2013-03-04T14:36:00Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2001-03 | - |
dc.identifier.citation | NATURE NEUROSCIENCE, v.4, no.3, pp.282 - 288 | - |
dc.identifier.issn | 1097-6256 | - |
dc.identifier.uri | http://hdl.handle.net/10203/82967 | - |
dc.description.abstract | During development of the cerebral cortex, the invasion of thalamic axons and subsequent differentiation of cortical neurons are tightly coordinated. Here we provide evidence that glutamate neurotransmission triggers a critical signaling mechanism involving the activation of phospholipase C-beta1 (PLC-beta1) by metabotropic glutamate receptors (mGluRs). Homozygous null mutation of either PLC-beta1 or mGluR5 dramatically disrupts the cytoarchitectural differentiation of 'barrels' in the mouse somatosensory cortex, despite segregation in the pattern of thalamic innervation. Furthermore, group 1 mGluR-stimulated phosphoinositide hydrolysis is dramatically reduced in PLC-beta1(-/-) mice during barrel development. Our data indicate that PLC-beta1 activation via mGluR5 is critical for the coordinated development of the neocortex, and that presynaptic and postsynaptic components of cortical differentiation can be genetically dissociated. | - |
dc.language | English | - |
dc.publisher | Nature magazine | - |
dc.subject | METABOTROPIC GLUTAMATE RECEPTORS | - |
dc.subject | LONG-TERM POTENTIATION | - |
dc.subject | MOUSE SOMATOSENSORY CORTEX | - |
dc.subject | CAT VISUAL-CORTEX | - |
dc.subject | CRITICAL PERIOD | - |
dc.subject | MONOAMINE-OXIDASE | - |
dc.subject | BARREL CORTEX | - |
dc.subject | POSTNATAL-DEVELOPMENT | - |
dc.subject | PATTERN-FORMATION | - |
dc.subject | RAT | - |
dc.title | PLC-beta1, activated via mGluRs, mediates activity-dependent differentiation in cerebral cortex | - |
dc.type | Article | - |
dc.identifier.wosid | 000167178300016 | - |
dc.identifier.scopusid | 2-s2.0-0034745927 | - |
dc.type.rims | ART | - |
dc.citation.volume | 4 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 282 | - |
dc.citation.endingpage | 288 | - |
dc.citation.publicationname | NATURE NEUROSCIENCE | - |
dc.identifier.doi | 10.1038/85132 | - |
dc.contributor.localauthor | Kim, Daesoo | - |
dc.contributor.nonIdAuthor | Hannan, Anthony J. | - |
dc.contributor.nonIdAuthor | Blakemore, Colin | - |
dc.contributor.nonIdAuthor | Katsnelson, Alla | - |
dc.contributor.nonIdAuthor | Vitalis, Tania | - |
dc.contributor.nonIdAuthor | Huber, Kimberly M. | - |
dc.contributor.nonIdAuthor | Bear, Mark | - |
dc.contributor.nonIdAuthor | Roder, John | - |
dc.contributor.nonIdAuthor | Shin, Hee-Sup | - |
dc.contributor.nonIdAuthor | Kind, Peter C. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | METABOTROPIC GLUTAMATE RECEPTORS | - |
dc.subject.keywordPlus | LONG-TERM POTENTIATION | - |
dc.subject.keywordPlus | MOUSE SOMATOSENSORY CORTEX | - |
dc.subject.keywordPlus | CAT VISUAL-CORTEX | - |
dc.subject.keywordPlus | CRITICAL PERIOD | - |
dc.subject.keywordPlus | MONOAMINE-OXIDASE | - |
dc.subject.keywordPlus | BARREL CORTEX | - |
dc.subject.keywordPlus | POSTNATAL-DEVELOPMENT | - |
dc.subject.keywordPlus | PATTERN-FORMATION | - |
dc.subject.keywordPlus | RAT | - |
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