PLC-beta1, activated via mGluRs, mediates activity-dependent differentiation in cerebral cortex

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During development of the cerebral cortex, the invasion of thalamic axons and subsequent differentiation of cortical neurons are tightly coordinated. Here we provide evidence that glutamate neurotransmission triggers a critical signaling mechanism involving the activation of phospholipase C-beta1 (PLC-beta1) by metabotropic glutamate receptors (mGluRs). Homozygous null mutation of either PLC-beta1 or mGluR5 dramatically disrupts the cytoarchitectural differentiation of 'barrels' in the mouse somatosensory cortex, despite segregation in the pattern of thalamic innervation. Furthermore, group 1 mGluR-stimulated phosphoinositide hydrolysis is dramatically reduced in PLC-beta1(-/-) mice during barrel development. Our data indicate that PLC-beta1 activation via mGluR5 is critical for the coordinated development of the neocortex, and that presynaptic and postsynaptic components of cortical differentiation can be genetically dissociated.
Publisher
Nature magazine
Issue Date
2001-03
Language
English
Article Type
Article
Keywords

METABOTROPIC GLUTAMATE RECEPTORS; LONG-TERM POTENTIATION; MOUSE SOMATOSENSORY CORTEX; CAT VISUAL-CORTEX; CRITICAL PERIOD; MONOAMINE-OXIDASE; BARREL CORTEX; POSTNATAL-DEVELOPMENT; PATTERN-FORMATION; RAT

Citation

NATURE NEUROSCIENCE, v.4, no.3, pp.282 - 288

ISSN
1097-6256
DOI
10.1038/85132
URI
http://hdl.handle.net/10203/82967
Appears in Collection
BS-Journal Papers(저널논문)
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