DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, JS | ko |
dc.contributor.author | Jeon, YJ | ko |
dc.contributor.author | Suh, JH | ko |
dc.contributor.author | Park, SK | ko |
dc.contributor.author | Yang, Kyu Hwan | ko |
dc.contributor.author | Kim, HM | ko |
dc.date.accessioned | 2013-03-04T13:45:44Z | - |
dc.date.available | 2013-03-04T13:45:44Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2004-01 | - |
dc.identifier.citation | CANCER LETTERS, v.203, no.1, pp.91 - 98 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.uri | http://hdl.handle.net/10203/82828 | - |
dc.description.abstract | In the present study, we demonstrate the inhibitory effect of 2-acetylaminofluorene (AAF) on interleukin-1beta (IL-1beta) gene expression in lipopolysaccharide (LPS)-stimulated macrophages. Acetylaminofluorene inhibited IL-1 production in LPS-stimulated splenic macrophages and RAW 264.7 cells. Additionally, AAF also suppressed LPS-induced mRNA expression of IL-1beta in macrophages. To further characterize the molecular mechanism responsible for AAF-mediated suppression of IL-1beta, we investigated the effect of AAF on LPS-mediated activation of transcription factors, such as NF-kappaB, AP-1, CRE and NF-IL6, which are to be important for LPS-induced gene expression of IL-1beta. Treatment of AAF caused a dose-related inhibition of LPS-induced NF-kappaB/Rel transcriptional activation, while the transcriptional activation of AP-1, CRE and NF-IL6 was not affected by AAF. Furthermore, LPS-induced NF-kappaB/Rel DNA binding was also suppressed by AAF treatment. These results suggest that AAF inhibits IL-1beta gene expression by blocking NF-kappaB/Rel activation. (C) 2004 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | English | - |
dc.publisher | Elsevier Ireland Ltd | - |
dc.subject | NITRIC-OXIDE SYNTHASE | - |
dc.subject | RECEPTOR ANTAGONIST | - |
dc.subject | MURINE SPLENOCYTES | - |
dc.subject | DOWN-REGULATION | - |
dc.subject | EXPRESSION | - |
dc.subject | TRANSCRIPTION | - |
dc.subject | CANCER | - |
dc.subject | GENE | - |
dc.subject | GROWTH | - |
dc.subject | KINASE | - |
dc.title | 2-Acetylaminofluorene inhibits interleukin-1 beta production in LPS-stimulated macrophages by blocking NF-kappa B/Rel activation | - |
dc.type | Article | - |
dc.identifier.wosid | 000187858100011 | - |
dc.identifier.scopusid | 2-s2.0-0344304769 | - |
dc.type.rims | ART | - |
dc.citation.volume | 203 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 91 | - |
dc.citation.endingpage | 98 | - |
dc.citation.publicationname | CANCER LETTERS | - |
dc.identifier.doi | 10.1016/j.canlet.2003.08.014 | - |
dc.contributor.nonIdAuthor | Kang, JS | - |
dc.contributor.nonIdAuthor | Jeon, YJ | - |
dc.contributor.nonIdAuthor | Suh, JH | - |
dc.contributor.nonIdAuthor | Park, SK | - |
dc.contributor.nonIdAuthor | Kim, HM | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | 2-Acetylaminofluorene | - |
dc.subject.keywordAuthor | interleukin-1 beta | - |
dc.subject.keywordAuthor | NF-KB/Rel | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | RECEPTOR ANTAGONIST | - |
dc.subject.keywordPlus | MURINE SPLENOCYTES | - |
dc.subject.keywordPlus | DOWN-REGULATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | KINASE | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.