DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ding, H | ko |
dc.contributor.author | Wu, XL | ko |
dc.contributor.author | Bostrom, H | ko |
dc.contributor.author | Kim, Injune | ko |
dc.contributor.author | Wong, N | ko |
dc.contributor.author | Tsoi, B | ko |
dc.contributor.author | O'Rourke, M | ko |
dc.contributor.author | Koh, Gou Young | ko |
dc.contributor.author | Soriano, P | ko |
dc.contributor.author | Betsholtz, C | ko |
dc.contributor.author | Hart, TC | ko |
dc.contributor.author | Marazita, ML | ko |
dc.contributor.author | Field, LL | ko |
dc.contributor.author | Tam, PPL | ko |
dc.contributor.author | Nagy, A | ko |
dc.date.accessioned | 2013-03-04T13:25:03Z | - |
dc.date.available | 2013-03-04T13:25:03Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2004-10 | - |
dc.identifier.citation | NATURE GENETICS, v.36, no.10, pp.1111 - 1116 | - |
dc.identifier.issn | 1061-4036 | - |
dc.identifier.uri | http://hdl.handle.net/10203/82776 | - |
dc.description.abstract | PDGF-C is a member of the platelet-derived growth factor (PDGF) family, which signals through PDGF receptor (PDGFR) alphaalpha and alphabeta dimers(1,2). Here we show that Pdgfc(-/-) mice die in the perinatal period owing to feeding and respiratory difficulties associated with a complete cleft of the secondary palate. This phenotype was less severe than that of Pdgfra(-/-) embryos. Pdgfc(-/-) Pdgfa(-/-) embryos developed a cleft face, subepidermal blistering, deficiency of renal cortex mesenchyme, spina bifida and skeletal and vascular defects. Complete loss of function of both ligands, therefore, phenocopied the loss of PDGFR-alpha function, suggesting that both PDGF-A and PDGF-C signal through PDGFR-alpha to regulate the development of craniofacial structures, the neural tube and mesodermal organs. Our results also show that PDGF-C signaling is a new pathway in palatogenesis, different from, and independent of, those previously implicated. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | CELL-CELL ADHESION | - |
dc.subject | CLEFT-PALATE | - |
dc.subject | KNOCKOUT MICE | - |
dc.subject | BETA-RECEPTOR | - |
dc.subject | EXPRESSION | - |
dc.subject | ROLES | - |
dc.subject | DEFICIENT | - |
dc.subject | MUTATIONS | - |
dc.subject | TISSUES | - |
dc.subject | FUSION | - |
dc.title | A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling | - |
dc.type | Article | - |
dc.identifier.wosid | 000224156500021 | - |
dc.identifier.scopusid | 2-s2.0-6944220086 | - |
dc.type.rims | ART | - |
dc.citation.volume | 36 | - |
dc.citation.issue | 10 | - |
dc.citation.beginningpage | 1111 | - |
dc.citation.endingpage | 1116 | - |
dc.citation.publicationname | NATURE GENETICS | - |
dc.identifier.doi | 10.1038/ng1415 | - |
dc.contributor.localauthor | Kim, Injune | - |
dc.contributor.localauthor | Koh, Gou Young | - |
dc.contributor.nonIdAuthor | Ding, H | - |
dc.contributor.nonIdAuthor | Wu, XL | - |
dc.contributor.nonIdAuthor | Bostrom, H | - |
dc.contributor.nonIdAuthor | Wong, N | - |
dc.contributor.nonIdAuthor | Tsoi, B | - |
dc.contributor.nonIdAuthor | O'Rourke, M | - |
dc.contributor.nonIdAuthor | Soriano, P | - |
dc.contributor.nonIdAuthor | Betsholtz, C | - |
dc.contributor.nonIdAuthor | Hart, TC | - |
dc.contributor.nonIdAuthor | Marazita, ML | - |
dc.contributor.nonIdAuthor | Field, LL | - |
dc.contributor.nonIdAuthor | Tam, PPL | - |
dc.contributor.nonIdAuthor | Nagy, A | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | CELL-CELL ADHESION | - |
dc.subject.keywordPlus | CLEFT-PALATE | - |
dc.subject.keywordPlus | KNOCKOUT MICE | - |
dc.subject.keywordPlus | BETA-RECEPTOR | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ROLES | - |
dc.subject.keywordPlus | DEFICIENT | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | TISSUES | - |
dc.subject.keywordPlus | FUSION | - |
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