Optical Multistage Interconnection Networks(OMINs) comprising photonic switches have been studied extensively as important interconnecting building blocks for communication networks and parallel computing systems. A basic element of photonic switching networks is a 2x2 directional coupler with two inputs and two outputs. This paper is concerned with the diagnosis of cross-talk-faults in OMINs. As the size of todays network becomes very large, the conventional diagnosis methods based on tests and simulation have become inefficient, or even more, impractical. In this paper, we propose a simple and easily implementable algorithm for detection and isolation of the single crosstalk-fault in OMINs. Specifically, we develope an algorithm fur the isolation of the source fault in switching elements whenever the single crosstalk-fault is detected in OMINS. The proposed algorithm is illustrated by an example of 16x16 banyan network.