Immunosuppressive effects of tautomycetin in vivo and in vitro via T cell-specific apoptosis induction

Cited 44 time in webofscience Cited 50 time in scopus
  • Hit : 426
  • Download : 0
Tautomycetin (TMC) was identified as an immunosuppressor of activated T cells. Inhibition of T cell proliferation with TMC was observed at concentrations 100-fold lower than those needed to achieve maximal inhibition with cyclosporin A (CsA). TMC specifically blocked tyrosine phosphorylation of intracellular signal mediators downstream of Src tyrosine kinases in a T cell-specific manner, leading to apoptosis due to cleavage of Bcl-2, caspase-9, caspase-3, and poly(ADP-ribose) polymerase, but not caspase-1. In TMC-treated rats that received a heterotopic cardiac allograft, the graft survived more than 160 days, comparable to graft survival in allografted rats treated with CsA. Thus, TMC, whose mechanism of action is different from that of CsA or FK506, can be used as a potent T cell-specific immunosuppressor.
Publisher
NATL ACAD SCIENCES
Issue Date
2002-08
Language
English
Article Type
Article
Keywords

SIGNAL-TRANSDUCTION; B-CELL; ACTIVATION; RECEPTOR; ANTIGEN; LYMPHOCYTES; INHIBITION; RAPAMYCIN; PATHWAYS; AGENTS

Citation

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.99, no.16, pp.10617 - 10622

ISSN
0027-8424
DOI
10.1073/pnas.162522099
URI
http://hdl.handle.net/10203/81569
Appears in Collection
MSE-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 44 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0