Localization of Tie2 and phospholipase D in endothelial caveolae is involved in angiopoietin-1-induced MEK/ERK phosphorylation and migration in endothelial cells

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dc.contributor.authorYoon, Mko
dc.contributor.authorCho, CHko
dc.contributor.authorLee, CSko
dc.contributor.authorJang, IHko
dc.contributor.authorRyu, SHko
dc.contributor.authorKoh, Gou Youngko
dc.date.accessioned2013-03-04T01:39:08Z-
dc.date.available2013-03-04T01:39:08Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2003-08-
dc.identifier.citationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.308, pp.101 - 105-
dc.identifier.issn0006-291X-
dc.identifier.urihttp://hdl.handle.net/10203/81345-
dc.description.abstractAngiopoietin-1 (Ang1) and its receptor, Tie2, play critical roles in blood vessel formation. Ang1 triggers a variety of signaling events in endothelial cells leading to vasculogenic and angiogenic processes. However, the underlying mechanism for Ang1/Tie2 signaling is not fully understood. Here, we show that Tie2 and phospholipase D (PLD) are localized in the caveolae, specialized subdomains of the endothelial cell plasma membrane enriched with signaling molecules. Interestingly, Ang1 increased PLD activities in a dose- and time-dependent manner. Ang1-induced MEK/ERK activation was abrogated when PLD was inhibited, suggesting that PLD mediates Ang1-induced MEK/ERK activation. Moreover, PLD inhibitor, 1-butanol, inhibited Ang1-induced endothelial cell migration. Our results indicate that: (1) caveolae may be the platform for Tie2/PLD association in endothelial cells; (2) PLD is a new mediator of Ang1/Tie2-induced signaling pathway, and it participates in MAPK activation and endothelial cell migration. (C) 2003 Elsevier Inc. All rights reserved.-
dc.languageEnglish-
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE-
dc.subjectSIGNAL-TRANSDUCTION-
dc.subjectGROWTH-FACTORS-
dc.subjectLIPID RAFTS-
dc.subjectACTIVATION-
dc.subjectSURVIVAL-
dc.subjectTRANSLOCATION-
dc.subjectEXPRESSION-
dc.subjectCLONING-
dc.subjectPROTEIN-
dc.subjectBINDING-
dc.titleLocalization of Tie2 and phospholipase D in endothelial caveolae is involved in angiopoietin-1-induced MEK/ERK phosphorylation and migration in endothelial cells-
dc.typeArticle-
dc.identifier.wosid000184602100016-
dc.identifier.scopusid2-s2.0-0042850313-
dc.type.rimsART-
dc.citation.volume308-
dc.citation.beginningpage101-
dc.citation.endingpage105-
dc.citation.publicationnameBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.identifier.doi10.1016/S0006-291X(03)01341-X-
dc.contributor.localauthorKoh, Gou Young-
dc.contributor.nonIdAuthorYoon, M-
dc.contributor.nonIdAuthorCho, CH-
dc.contributor.nonIdAuthorLee, CS-
dc.contributor.nonIdAuthorJang, IH-
dc.contributor.nonIdAuthorRyu, SH-
dc.type.journalArticleArticle-
dc.subject.keywordPlusSIGNAL-TRANSDUCTION-
dc.subject.keywordPlusGROWTH-FACTORS-
dc.subject.keywordPlusLIPID RAFTS-
dc.subject.keywordPlusACTIVATION-
dc.subject.keywordPlusSURVIVAL-
dc.subject.keywordPlusTRANSLOCATION-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusCLONING-
dc.subject.keywordPlusPROTEIN-
dc.subject.keywordPlusBINDING-
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