DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoon, M | ko |
dc.contributor.author | Cho, CH | ko |
dc.contributor.author | Lee, CS | ko |
dc.contributor.author | Jang, IH | ko |
dc.contributor.author | Ryu, SH | ko |
dc.contributor.author | Koh, Gou Young | ko |
dc.date.accessioned | 2013-03-04T01:39:08Z | - |
dc.date.available | 2013-03-04T01:39:08Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2003-08 | - |
dc.identifier.citation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.308, pp.101 - 105 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | http://hdl.handle.net/10203/81345 | - |
dc.description.abstract | Angiopoietin-1 (Ang1) and its receptor, Tie2, play critical roles in blood vessel formation. Ang1 triggers a variety of signaling events in endothelial cells leading to vasculogenic and angiogenic processes. However, the underlying mechanism for Ang1/Tie2 signaling is not fully understood. Here, we show that Tie2 and phospholipase D (PLD) are localized in the caveolae, specialized subdomains of the endothelial cell plasma membrane enriched with signaling molecules. Interestingly, Ang1 increased PLD activities in a dose- and time-dependent manner. Ang1-induced MEK/ERK activation was abrogated when PLD was inhibited, suggesting that PLD mediates Ang1-induced MEK/ERK activation. Moreover, PLD inhibitor, 1-butanol, inhibited Ang1-induced endothelial cell migration. Our results indicate that: (1) caveolae may be the platform for Tie2/PLD association in endothelial cells; (2) PLD is a new mediator of Ang1/Tie2-induced signaling pathway, and it participates in MAPK activation and endothelial cell migration. (C) 2003 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | SIGNAL-TRANSDUCTION | - |
dc.subject | GROWTH-FACTORS | - |
dc.subject | LIPID RAFTS | - |
dc.subject | ACTIVATION | - |
dc.subject | SURVIVAL | - |
dc.subject | TRANSLOCATION | - |
dc.subject | EXPRESSION | - |
dc.subject | CLONING | - |
dc.subject | PROTEIN | - |
dc.subject | BINDING | - |
dc.title | Localization of Tie2 and phospholipase D in endothelial caveolae is involved in angiopoietin-1-induced MEK/ERK phosphorylation and migration in endothelial cells | - |
dc.type | Article | - |
dc.identifier.wosid | 000184602100016 | - |
dc.identifier.scopusid | 2-s2.0-0042850313 | - |
dc.type.rims | ART | - |
dc.citation.volume | 308 | - |
dc.citation.beginningpage | 101 | - |
dc.citation.endingpage | 105 | - |
dc.citation.publicationname | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.identifier.doi | 10.1016/S0006-291X(03)01341-X | - |
dc.contributor.localauthor | Koh, Gou Young | - |
dc.contributor.nonIdAuthor | Yoon, M | - |
dc.contributor.nonIdAuthor | Cho, CH | - |
dc.contributor.nonIdAuthor | Lee, CS | - |
dc.contributor.nonIdAuthor | Jang, IH | - |
dc.contributor.nonIdAuthor | Ryu, SH | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION | - |
dc.subject.keywordPlus | GROWTH-FACTORS | - |
dc.subject.keywordPlus | LIPID RAFTS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | TRANSLOCATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CLONING | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | BINDING | - |
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