DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jiyun | ko |
dc.contributor.author | Lee, Daeyoup | ko |
dc.contributor.author | Hwang, Sun Gwan | ko |
dc.contributor.author | Hwang, Eun-Seong | ko |
dc.contributor.author | Choe, Joonho | ko |
dc.date.accessioned | 2013-03-03T22:49:57Z | - |
dc.date.available | 2013-03-03T22:49:57Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2003-06 | - |
dc.identifier.citation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.305, no.4, pp.1008 - 1016 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | http://hdl.handle.net/10203/80794 | - |
dc.description.abstract | BRCA1 is a breast and ovarian cancer-related tumor suppressor and has a role in transcriptional activation. We show here that BRCA1 enhances human papillomavirus type 18 (HPV-18) E2-dependent transcription in vivo. Using biochemical approaches. we discovered that BRCA1 interacts with the carboxyl-terminus of HPV-18 E2 protein in vivo and in vitro. Point mutations in the G terminus make BRCA1 defective in transcriptional activation in E2-dependent transcription. This finding suggests that the C-terminus of BRCA1 is important for E2-dependent transcription. A chromatin immunoprecipitation assay indicated that BRCA1 is recruited onto the E2-dependent promoter region though E2 tethered to E2 binding sites in vivo. These results implicate that BRCA1 plays a role in E2-dependent transcription. (C) 2003 Elsevier Science (USA). All rights reserved. | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | CANCER SUSCEPTIBILITY GENE | - |
dc.subject | TERMINAL REGION | - |
dc.subject | TRANSACTIVATION DOMAIN | - |
dc.subject | FUNCTIONAL INTERACTION | - |
dc.subject | ONCOGENE EXPRESSION | - |
dc.subject | GROWTH-INHIBITION | - |
dc.subject | ACTIVATION | - |
dc.subject | PROTEINS | - |
dc.subject | BREAST | - |
dc.subject | CELLS | - |
dc.title | BRCA1 associates with human papillomavirus type 18 E2 and stimulates E2-dependent transcription | - |
dc.type | Article | - |
dc.identifier.wosid | 000183578500034 | - |
dc.identifier.scopusid | 2-s2.0-0038242281 | - |
dc.type.rims | ART | - |
dc.citation.volume | 305 | - |
dc.citation.issue | 4 | - |
dc.citation.beginningpage | 1008 | - |
dc.citation.endingpage | 1016 | - |
dc.citation.publicationname | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.contributor.localauthor | Lee, Daeyoup | - |
dc.contributor.localauthor | Choe, Joonho | - |
dc.contributor.nonIdAuthor | Kim, Jiyun | - |
dc.contributor.nonIdAuthor | Hwang, Sun Gwan | - |
dc.contributor.nonIdAuthor | Hwang, Eun-Seong | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | coactivator | - |
dc.subject.keywordAuthor | BRCA1 | - |
dc.subject.keywordAuthor | papillomavirus | - |
dc.subject.keywordPlus | CANCER SUSCEPTIBILITY GENE | - |
dc.subject.keywordPlus | TERMINAL REGION | - |
dc.subject.keywordPlus | TRANSACTIVATION DOMAIN | - |
dc.subject.keywordPlus | FUNCTIONAL INTERACTION | - |
dc.subject.keywordPlus | ONCOGENE EXPRESSION | - |
dc.subject.keywordPlus | GROWTH-INHIBITION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | BREAST | - |
dc.subject.keywordPlus | CELLS | - |
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