DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Daeyoup | ko |
dc.contributor.author | Kim, Jin Woo | ko |
dc.contributor.author | Kim, Karam | ko |
dc.contributor.author | Joe, Cheol O | ko |
dc.contributor.author | Schreiber, Valérie | ko |
dc.contributor.author | Menissier-de Murcia, J | ko |
dc.contributor.author | Choe, Joonho | ko |
dc.date.accessioned | 2013-03-03T21:32:17Z | - |
dc.date.available | 2013-03-03T21:32:17Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2002-08 | - |
dc.identifier.citation | ONCOGENE, v.21, no.38, pp.5877 - 5885 | - |
dc.identifier.issn | 0950-9232 | - |
dc.identifier.uri | http://hdl.handle.net/10203/80536 | - |
dc.description.abstract | Human papillomavirus E2 protein is a transcription factor of viral gene expression and DNA replication. Here we show that PARP is a positive regulator of the E2 protein of human papillomavirus type 18 (HPV-18). PARP interacted with the COOH terminal region of HPV-18 E2 in vitro. The E2 interaction domain within PARP is located in the NH2-terminal zinc finger motif and the BRCT motif included in the automodification domain. Overexpression of either wild type or the NH2-terminal region of PARP containing zinc finger and BRCT stimulated E2-dependent transcription. Gel retardation assay indicates that PARP augments DNA binding activity of E2 in vitro. We also show that PARP-1 is recruited to E2-dependent promoter in vivo using ChIP assay. These results suggest that PARP serves a transcriptional co-activator in E2-dependent transcription by interacting directly with the HPV E2 protein. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | CALCIUM-INDUCED DIFFERENTIATION | - |
dc.subject | HUMAN KERATINOCYTES | - |
dc.subject | ADP-RIBOSYLATION | - |
dc.subject | TRANSCRIPTIONAL REPRESSOR | - |
dc.subject | CELL-DIFFERENTIATION | - |
dc.subject | MAMMALIAN-CELLS | - |
dc.subject | E7 ONCOPROTEIN | - |
dc.subject | E6 ONCOPROTEIN | - |
dc.subject | EARLY PROMOTER | - |
dc.subject | HELA-CELLS | - |
dc.title | Functional interaction between human papillomavirus type 18 E2 and poly(ADP-ribose) polymerase 1 | - |
dc.type | Article | - |
dc.identifier.wosid | 000177520900007 | - |
dc.identifier.scopusid | 2-s2.0-0037194614 | - |
dc.type.rims | ART | - |
dc.citation.volume | 21 | - |
dc.citation.issue | 38 | - |
dc.citation.beginningpage | 5877 | - |
dc.citation.endingpage | 5885 | - |
dc.citation.publicationname | ONCOGENE | - |
dc.contributor.localauthor | Lee, Daeyoup | - |
dc.contributor.localauthor | Kim, Jin Woo | - |
dc.contributor.localauthor | Joe, Cheol O | - |
dc.contributor.localauthor | Choe, Joonho | - |
dc.contributor.nonIdAuthor | Kim, Karam | - |
dc.contributor.nonIdAuthor | Schreiber, Valérie | - |
dc.contributor.nonIdAuthor | Menissier-de Murcia, J | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | PARP | - |
dc.subject.keywordAuthor | HPV | - |
dc.subject.keywordAuthor | transcriptional activation | - |
dc.subject.keywordPlus | CALCIUM-INDUCED DIFFERENTIATION | - |
dc.subject.keywordPlus | HUMAN KERATINOCYTES | - |
dc.subject.keywordPlus | ADP-RIBOSYLATION | - |
dc.subject.keywordPlus | TRANSCRIPTIONAL REPRESSOR | - |
dc.subject.keywordPlus | CELL-DIFFERENTIATION | - |
dc.subject.keywordPlus | MAMMALIAN-CELLS | - |
dc.subject.keywordPlus | E7 ONCOPROTEIN | - |
dc.subject.keywordPlus | E6 ONCOPROTEIN | - |
dc.subject.keywordPlus | EARLY PROMOTER | - |
dc.subject.keywordPlus | HELA-CELLS | - |
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