DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wyszynski, M | ko |
dc.contributor.author | Kim, Eunjoon | ko |
dc.contributor.author | Dunah, AW | ko |
dc.contributor.author | Passafaro, M | ko |
dc.contributor.author | Valtschanoff, JG | ko |
dc.contributor.author | Serra-Pages, C | ko |
dc.contributor.author | Streuli, M | ko |
dc.contributor.author | Weinberg, RJ | ko |
dc.contributor.author | Sheng, M | ko |
dc.date.accessioned | 2013-03-03T19:19:47Z | - |
dc.date.available | 2013-03-03T19:19:47Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2002-03 | - |
dc.identifier.citation | NEURON, v.34, no.1, pp.39 - 52 | - |
dc.identifier.issn | 0896-6273 | - |
dc.identifier.uri | http://hdl.handle.net/10203/80090 | - |
dc.description.abstract | Interaction with the multi-PDZ protein GRIP is required for the synaptic targeting of AMPA receptors, but the underlying mechanism is unknown. We show that GRIP binds to the liprin-alpha/SYD2 family of proteins that interact with LAR receptor protein tyrosine phosphatases (LAR-RPTPs) and that are implicated in presynaptic development. In neurons, liprin-alpha and LAR-RPTP are enriched at synapses and coimmunoprecipitate with GRIP and AMPA receptors. Dominant-negative constructs that interfere with the GRIP-liprin interaction disrupt the surface expression and dendritic clustering of AMPA receptors in cultured neurons. Thus, by mediating the targeting of liprin/GRIP-associated proteins, liprin-alpha is important for postsynaptic as well as presynaptic maturation. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.subject | PROTEIN-TYROSINE-PHOSPHATASE | - |
dc.subject | MOTOR AXON GUIDANCE | - |
dc.subject | FAMILY | - |
dc.subject | LAR | - |
dc.subject | BINDING | - |
dc.subject | DROSOPHILA | - |
dc.subject | PLASTICITY | - |
dc.subject | EXPRESSION | - |
dc.subject | LIGANDS | - |
dc.subject | CLUSTER | - |
dc.title | Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting | - |
dc.type | Article | - |
dc.identifier.wosid | 000174695100008 | - |
dc.identifier.scopusid | 2-s2.0-0037187640 | - |
dc.type.rims | ART | - |
dc.citation.volume | 34 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 39 | - |
dc.citation.endingpage | 52 | - |
dc.citation.publicationname | NEURON | - |
dc.contributor.localauthor | Kim, Eunjoon | - |
dc.contributor.nonIdAuthor | Wyszynski, M | - |
dc.contributor.nonIdAuthor | Dunah, AW | - |
dc.contributor.nonIdAuthor | Passafaro, M | - |
dc.contributor.nonIdAuthor | Valtschanoff, JG | - |
dc.contributor.nonIdAuthor | Serra-Pages, C | - |
dc.contributor.nonIdAuthor | Streuli, M | - |
dc.contributor.nonIdAuthor | Weinberg, RJ | - |
dc.contributor.nonIdAuthor | Sheng, M | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | PROTEIN-TYROSINE-PHOSPHATASE | - |
dc.subject.keywordPlus | MOTOR AXON GUIDANCE | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordPlus | LAR | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | DROSOPHILA | - |
dc.subject.keywordPlus | PLASTICITY | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | LIGANDS | - |
dc.subject.keywordPlus | CLUSTER | - |
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