The unequally spaced non-periodic B-spline finite strip method (FSM) is presented. The motivation to investigate the irregularly spaced interior nodes in the longitudinal direction of strip is to generalize the concept of non-periodic B-spline FSM and to improve the general accuracy of the stress evaluation in the region of high stress gradients. In the present paper, the unequally spaced non-periodic B3-spline series with multiple knots at the boundary are introduced for the interpolation of displacement and description of geometry in the formulation of isoparametric spline FSM. The use of multiple knots at the boundary makes the shape function satisfy the Kronecker delta properties at the boundary. The unequally spaced B-spline FSM is applied to the stress-reduced shell problem with six degrees of freedom per node. The main purpose of this study is to find a way of ensuring that the geometry of strip is appropriately approximated when the interior nodes of the strip are not regularly spaced along the longitudinal direction. Some numerical results have been compared with those of the previous studies to evaluate the accuracy and efficiency of this method. Copyright (C) 2003 John Wiley Sons, Ltd.