Potent neurotoxins: Tetrodotoxin, chiriquitoxin, and zetekitoxin from Atelopus frogs in Central America

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A mixture of the potent neurotoxins tetrodotoxin (TTX) and chiriquitoxin (CHTX) was isolated from the skins of the male and the eggs of the female frog Atelopus chiriquiensis from Costa Rica. Tetrodotoxin was also found in the skin of both populations of Atelopus varius varius and Atelopus varius ambulatorious from Costa Rica. Zetekitoxin(ZTX) was isolated from Atelopus zeteki from Panama. The TTX, CHTX, and ZTX are potent neurotoxins and their toxicities are about the same (ca. 5-11 mug/Kg). The structural studies and biological activities of TTX, CHTX, and ZTX are described.
Publisher
MARCEL DEKKER INC
Issue Date
2003
Language
English
Article Type
Article; Proceedings Paper
Keywords

COSTA RICAN FROG; ATELOPIDTOXIN; CHIRIQUIENSIS; TARICHATOXIN; TOXINS; SKIN; NEWT

Citation

JOURNAL OF TOXICOLOGY-TOXIN REVIEWS, v.22, no.4, pp.521 - 532

ISSN
0731-3837
DOI
10.1081/TXR-120026911
URI
http://hdl.handle.net/10203/79941
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