DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hwang, Seungmin | ko |
dc.contributor.author | Gwack, Yousang | ko |
dc.contributor.author | Byun, Hyewon | ko |
dc.contributor.author | Lim, Chunghun | ko |
dc.contributor.author | Choe, Joonho | ko |
dc.date.accessioned | 2013-03-03T14:15:38Z | - |
dc.date.available | 2013-03-03T14:15:38Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2001-10 | - |
dc.identifier.citation | JOURNAL OF VIROLOGY, v.75, no.19, pp.9509 - 9516 | - |
dc.identifier.issn | 0022-538X | - |
dc.identifier.uri | http://hdl.handle.net/10203/79036 | - |
dc.description.abstract | Kaposi's sarcoma-associated herpesvirus (KSHV) open reading frame K8 encodes a basic region-leucine zipper protein of 237 amino acids that homodimerizes with its bZIP domain. KSHV K8 shows significant homology to the Epstein-Barr virus (EBV) immediate-early protein Zta, a key regulator in the reactivation and replication of EBV. In this study, we report that K8, like its homolog EBV Zta, interacts with cellular CREB-binding protein (CBP) in vivo and in vitro. This interaction requires the C/H3 domain of CBP and the basic region of K8. K8 represses CBP-mediated transcription by competing with limited amounts of cellular CBP, exemplified by the reduced expression from the AP-1 and human immunodeficiency virus long terminal repeat promoters. | - |
dc.language | English | - |
dc.publisher | AMER SOC MICROBIOLOGY | - |
dc.title | The Kaposi's sarcoma-associated herpesvirus K8 protein interacts with CREB-binding protein (CBP) and represses CBP-mediated transcription | - |
dc.type | Article | - |
dc.identifier.wosid | 000170898600063 | - |
dc.identifier.scopusid | 2-s2.0-0034842669 | - |
dc.type.rims | ART | - |
dc.citation.volume | 75 | - |
dc.citation.issue | 19 | - |
dc.citation.beginningpage | 9509 | - |
dc.citation.endingpage | 9516 | - |
dc.citation.publicationname | JOURNAL OF VIROLOGY | - |
dc.identifier.doi | 10.1128/JVI.75.19.9509-9516.2001 | - |
dc.contributor.localauthor | Lim, Chunghun | - |
dc.contributor.localauthor | Choe, Joonho | - |
dc.contributor.nonIdAuthor | Hwang, Seungmin | - |
dc.contributor.nonIdAuthor | Gwack, Yousang | - |
dc.contributor.nonIdAuthor | Byun, Hyewon | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | EPSTEIN-BARR-VIRUS | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | BZIP PROTEIN | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | P300 | - |
dc.subject.keywordPlus | COACTIVATORS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | E1A | - |
dc.subject.keywordPlus | HUMAN-HERPESVIRUS-8 | - |
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