Taguchi's method was attempted successfully to optimize the reaction variables and their ranges for sucrose monoester production. Optimal conditions determined by Taguchi's method were 35 degrees C, 200rpm, capric acid (40mmol) and sucrose (3mmol), 24h, 0.5g lipase, 0.72g Ba(OH)(2) . 8H(2)O, 0.72g Ba(OH)(2) . 1H(2)O. A product yield of 21% was obtained.