DC Field | Value | Language |
---|---|---|
dc.contributor.author | MookJung, I | ko |
dc.contributor.author | Joo, I | ko |
dc.contributor.author | Sohn, S | ko |
dc.contributor.author | Kwon, HJ | ko |
dc.contributor.author | Huh, K | ko |
dc.contributor.author | Jung, MW | ko |
dc.date.accessioned | 2013-03-03T09:17:37Z | - |
dc.date.available | 2013-03-03T09:17:37Z | - |
dc.date.created | 2013-02-21 | - |
dc.date.created | 2013-02-21 | - |
dc.date.issued | 1997-10 | - |
dc.identifier.citation | NEUROSCIENCE LETTERS, v.235, no.3, pp.101 - 104 | - |
dc.identifier.issn | 0304-3940 | - |
dc.identifier.uri | http://hdl.handle.net/10203/78162 | - |
dc.description.abstract | Clinical studies have shown that estrogen replacement therapy is associated with reduced risk of Alzheimer's disease (AD). We tested whether or not estrogen blocks neurotoxic effects of beta-amyloid (1-42) (A beta(1-42)) on cultured B103 cells. A beta(1-42) (1 mu M) induced typical necrotic cell death, as revealed by light and electron microscopic examinations. Go-administration of estrogen not only blocked A beta(1-42) toxicity to a large degree, but also enhanced neurite extension. Pretreatment with estrogen was even more effective in blocking A beta(1-42) toxicity. When added 18 h after the beginning of A beta(1-42) treatment, estrogen was still effective in halting the progress of cell death and enhancing neurite extension. The protection against A beta(1-42)-induced neuronal death by estrogen was unlikely due to a blockade of lipid peroxidation injury, since estrogen completely failed to attenuate ferrous chloride-induced cell death. These results demonstrate that estrogen blocks A beta(1-42)-induced neurotoxicity and enhances neurite extension on B103 cells, both of which may well be underlying mechanisms of beneficial effects of estrogen in AD. (C) 1997 Elsevier Science Ireland Ltd. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCI IRELAND LTD | - |
dc.subject | FAMILIAL ALZHEIMERS-DISEASE | - |
dc.subject | CENTRAL-NERVOUS-SYSTEM | - |
dc.subject | ESTRADIOL PROTECTS | - |
dc.subject | PRECURSOR PROTEIN | - |
dc.subject | APOPTOSIS | - |
dc.subject | MUTATION | - |
dc.subject | NEURONS | - |
dc.subject | PLAQUES | - |
dc.subject | RISK | - |
dc.title | Estrogen blocks neurotoxic effects of beta-amyloid (1-42) and induces neurite extension on B103 cells | - |
dc.type | Article | - |
dc.identifier.wosid | A1997YF60600001 | - |
dc.identifier.scopusid | 2-s2.0-0031576349 | - |
dc.type.rims | ART | - |
dc.citation.volume | 235 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 101 | - |
dc.citation.endingpage | 104 | - |
dc.citation.publicationname | NEUROSCIENCE LETTERS | - |
dc.identifier.doi | 10.1016/S0304-3940(97)00632-0 | - |
dc.contributor.localauthor | Jung, MW | - |
dc.contributor.nonIdAuthor | MookJung, I | - |
dc.contributor.nonIdAuthor | Joo, I | - |
dc.contributor.nonIdAuthor | Sohn, S | - |
dc.contributor.nonIdAuthor | Kwon, HJ | - |
dc.contributor.nonIdAuthor | Huh, K | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | estrogen | - |
dc.subject.keywordAuthor | Alzheimer | - |
dc.subject.keywordAuthor | cell death | - |
dc.subject.keywordAuthor | necrosis | - |
dc.subject.keywordAuthor | neurite extension | - |
dc.subject.keywordAuthor | beta-amyloid | - |
dc.subject.keywordPlus | FAMILIAL ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | CENTRAL-NERVOUS-SYSTEM | - |
dc.subject.keywordPlus | ESTRADIOL PROTECTS | - |
dc.subject.keywordPlus | PRECURSOR PROTEIN | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | MUTATION | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | PLAQUES | - |
dc.subject.keywordPlus | RISK | - |
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