DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yun, SH | ko |
dc.contributor.author | Huh, K | ko |
dc.contributor.author | Jung, MW | ko |
dc.date.accessioned | 2013-03-03T08:39:54Z | - |
dc.date.available | 2013-03-03T08:39:54Z | - |
dc.date.created | 2013-02-20 | - |
dc.date.created | 2013-02-20 | - |
dc.date.issued | 2000-01 | - |
dc.identifier.citation | SYNAPSE, v.35, no.1, pp.1 - 7 | - |
dc.identifier.issn | 0887-4476 | - |
dc.identifier.uri | http://hdl.handle.net/10203/78006 | - |
dc.description.abstract | The contribution of NMDA receptors to the expression of long-term potentiation (LTP) is controversial. In entorhinal cortex (EC) previous studies reported either that LTP was exclusively expressed through NMDA receptors or that both NMDA and non-NMDA receptors were involved in LTP expression. To reexamine this issue, horizontal entorhinal cortical slices were prepared from adult rats and electrical stimulation was delivered in layer II/III, while field potential recordings were made in layer III. In the standard condition (2.5 mM Mg++), LTP was reliably induced by theta burst stimulation, but was blocked by 100 mu M D-APS, an NMDA receptor antagonist. This corroborates previous reports that NMDA receptor activation is required for induction of EC LTP. The field potential response was not affected by D-AP5, but completely blocked by 10 mu M CNQX, a non-NMDA receptor antagonist. This indicates that the expression of LTP is mediated by non-NMDA receptors in the standard condition. LTP of NMDA receptor-mediated responses was tested by comparing NMDA responses before and after applying theta burst stimulation in medium containing low magnesium (0.4-1 mM). Theta burst stimulation induced 43.2+/-9.7% increase of non-NMDA responses (i.e,, AP5-insensitive fast component) but 5.6+/-9.0% decrease of the NMDA receptor component (AP5-sensitive slow component). These results indicate that activation of NMDA receptors is critical for induction of LTP, but LTP expression is mediated by non-NMDA receptors in EC under these experimental conditions. Synapse 34:1-7, 2000. (C) 2000 Wiley-Liss, Inc. | - |
dc.language | English | - |
dc.publisher | WILEY-LISS | - |
dc.subject | RAT VISUAL-CORTEX | - |
dc.subject | GUINEA-PIG BRAIN | - |
dc.subject | SYNAPTIC TRANSMISSION | - |
dc.subject | PATTERNED STIMULATION | - |
dc.subject | PIRIFORM CORTEX | - |
dc.subject | HIPPOCAMPUS | - |
dc.subject | LTP | - |
dc.subject | EXPRESSION | - |
dc.subject | ACTIVATION | - |
dc.subject | INVITRO | - |
dc.title | Selective enhancement of non-NMDA receptor-mediated responses following induction of long-term potentiation in entorhinal cortex | - |
dc.type | Article | - |
dc.identifier.wosid | 000084078000001 | - |
dc.identifier.scopusid | 2-s2.0-0345073174 | - |
dc.type.rims | ART | - |
dc.citation.volume | 35 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 1 | - |
dc.citation.endingpage | 7 | - |
dc.citation.publicationname | SYNAPSE | - |
dc.identifier.doi | 10.1002/(SICI)1098-2396(200001)35:1<1::AID-SYN1>3.0.CO;2-L | - |
dc.contributor.localauthor | Jung, MW | - |
dc.contributor.nonIdAuthor | Yun, SH | - |
dc.contributor.nonIdAuthor | Huh, K | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | LTP | - |
dc.subject.keywordAuthor | memory | - |
dc.subject.keywordAuthor | hippocampus | - |
dc.subject.keywordAuthor | NMDA | - |
dc.subject.keywordAuthor | AP5 | - |
dc.subject.keywordPlus | RAT VISUAL-CORTEX | - |
dc.subject.keywordPlus | GUINEA-PIG BRAIN | - |
dc.subject.keywordPlus | SYNAPTIC TRANSMISSION | - |
dc.subject.keywordPlus | PATTERNED STIMULATION | - |
dc.subject.keywordPlus | PIRIFORM CORTEX | - |
dc.subject.keywordPlus | HIPPOCAMPUS | - |
dc.subject.keywordPlus | LTP | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | INVITRO | - |
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