Selective enhancement of non-NMDA receptor-mediated responses following induction of long-term potentiation in entorhinal cortex

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dc.contributor.authorYun, SHko
dc.contributor.authorHuh, Kko
dc.contributor.authorJung, MWko
dc.date.accessioned2013-03-03T08:39:54Z-
dc.date.available2013-03-03T08:39:54Z-
dc.date.created2013-02-20-
dc.date.created2013-02-20-
dc.date.issued2000-01-
dc.identifier.citationSYNAPSE, v.35, no.1, pp.1 - 7-
dc.identifier.issn0887-4476-
dc.identifier.urihttp://hdl.handle.net/10203/78006-
dc.description.abstractThe contribution of NMDA receptors to the expression of long-term potentiation (LTP) is controversial. In entorhinal cortex (EC) previous studies reported either that LTP was exclusively expressed through NMDA receptors or that both NMDA and non-NMDA receptors were involved in LTP expression. To reexamine this issue, horizontal entorhinal cortical slices were prepared from adult rats and electrical stimulation was delivered in layer II/III, while field potential recordings were made in layer III. In the standard condition (2.5 mM Mg++), LTP was reliably induced by theta burst stimulation, but was blocked by 100 mu M D-APS, an NMDA receptor antagonist. This corroborates previous reports that NMDA receptor activation is required for induction of EC LTP. The field potential response was not affected by D-AP5, but completely blocked by 10 mu M CNQX, a non-NMDA receptor antagonist. This indicates that the expression of LTP is mediated by non-NMDA receptors in the standard condition. LTP of NMDA receptor-mediated responses was tested by comparing NMDA responses before and after applying theta burst stimulation in medium containing low magnesium (0.4-1 mM). Theta burst stimulation induced 43.2+/-9.7% increase of non-NMDA responses (i.e,, AP5-insensitive fast component) but 5.6+/-9.0% decrease of the NMDA receptor component (AP5-sensitive slow component). These results indicate that activation of NMDA receptors is critical for induction of LTP, but LTP expression is mediated by non-NMDA receptors in EC under these experimental conditions. Synapse 34:1-7, 2000. (C) 2000 Wiley-Liss, Inc.-
dc.languageEnglish-
dc.publisherWILEY-LISS-
dc.subjectRAT VISUAL-CORTEX-
dc.subjectGUINEA-PIG BRAIN-
dc.subjectSYNAPTIC TRANSMISSION-
dc.subjectPATTERNED STIMULATION-
dc.subjectPIRIFORM CORTEX-
dc.subjectHIPPOCAMPUS-
dc.subjectLTP-
dc.subjectEXPRESSION-
dc.subjectACTIVATION-
dc.subjectINVITRO-
dc.titleSelective enhancement of non-NMDA receptor-mediated responses following induction of long-term potentiation in entorhinal cortex-
dc.typeArticle-
dc.identifier.wosid000084078000001-
dc.identifier.scopusid2-s2.0-0345073174-
dc.type.rimsART-
dc.citation.volume35-
dc.citation.issue1-
dc.citation.beginningpage1-
dc.citation.endingpage7-
dc.citation.publicationnameSYNAPSE-
dc.identifier.doi10.1002/(SICI)1098-2396(200001)35:1<1::AID-SYN1>3.0.CO;2-L-
dc.contributor.localauthorJung, MW-
dc.contributor.nonIdAuthorYun, SH-
dc.contributor.nonIdAuthorHuh, K-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorLTP-
dc.subject.keywordAuthormemory-
dc.subject.keywordAuthorhippocampus-
dc.subject.keywordAuthorNMDA-
dc.subject.keywordAuthorAP5-
dc.subject.keywordPlusRAT VISUAL-CORTEX-
dc.subject.keywordPlusGUINEA-PIG BRAIN-
dc.subject.keywordPlusSYNAPTIC TRANSMISSION-
dc.subject.keywordPlusPATTERNED STIMULATION-
dc.subject.keywordPlusPIRIFORM CORTEX-
dc.subject.keywordPlusHIPPOCAMPUS-
dc.subject.keywordPlusLTP-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusACTIVATION-
dc.subject.keywordPlusINVITRO-
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