Parasin I, an antimicrobial peptide derived from histone H2A in the catfish, Parasilurus asotus

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dc.contributor.authorPark, IYko
dc.contributor.authorPark, CBko
dc.contributor.authorKim, MSko
dc.contributor.authorKim, Sun-Changko
dc.date.accessioned2013-03-03T06:20:15Z-
dc.date.available2013-03-03T06:20:15Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued1998-10-
dc.identifier.citationFEBS LETTERS, v.437, no.3, pp.258 - 262-
dc.identifier.issn0014-5793-
dc.identifier.urihttp://hdl.handle.net/10203/77611-
dc.description.abstractIn response to epidermal injury, Pavasilurus asotus, a catfish, secreted a strong antimicrobial peptide into the epithelial mucosal layer. The molecular mass of the antimicrobial peptide, named parasin I, was 2000.4 Die, as determined by matrix-associated laser desorption ionization mass spectrometry. The complete amino acid sequence of parasin I, which was determined by automated Edman degradation, was Lys-Gly-Arg-Gly-Lys-Gln-Gly-Gly-Lys-Val-Arg-Ala-Lys-Ala-Lys-Thr-Arg-Ser-Ser. Eighteen of the 19 residues ia parasin I sere identical to the N-terminal of buforin I, ct 39-residue antimicrobial peptide derived from the N-terminal of toad histone H2A [Kim et al, (1996) Biochem. Biophys. Res. Commun. 229, 381-387], which implies that parasin I was cleaved off from the N-terminal of catfish histone H2A, Parasin I showed strong antimicrobial activity, about 12-100 times more potent than magainin 2, against a wide spectrum of microorganisms, without any hemolytic activity, Circular dichroism spectra of parasin I indicated a structural content of 11% alpha-helix, 33% beta-sheet, and 56% random coils. The beta-sheet axial projection diagram of parasin I showed an amphipathic structure. Our results indicate that the catfish may produce parasin I from its histone H2A by a specific protease upon injury to protect against invasion by microorganisms. (C) 1998 Federation of European Biochemical Societies.-
dc.languageEnglish-
dc.publisherELSEVIER SCIENCE BV-
dc.subjectXENOPUS-LAEVIS-
dc.subjectSKIN-
dc.subjectDEFENSINS-
dc.subjectCELLS-
dc.subjectCDNA-
dc.subjectANTIBIOTICS-
dc.subjectLACTOFERRIN-
dc.subjectSECRETION-
dc.subjectMELITTIN-
dc.subjectFRAGMENT-
dc.titleParasin I, an antimicrobial peptide derived from histone H2A in the catfish, Parasilurus asotus-
dc.typeArticle-
dc.identifier.wosid000076717700021-
dc.identifier.scopusid2-s2.0-0032561422-
dc.type.rimsART-
dc.citation.volume437-
dc.citation.issue3-
dc.citation.beginningpage258-
dc.citation.endingpage262-
dc.citation.publicationnameFEBS LETTERS-
dc.contributor.localauthorKim, Sun-Chang-
dc.contributor.nonIdAuthorPark, IY-
dc.contributor.nonIdAuthorPark, CB-
dc.contributor.nonIdAuthorKim, MS-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorantimicrobial peptide-
dc.subject.keywordAuthorhistone H2A-
dc.subject.keywordAuthorepidermal injury-
dc.subject.keywordAuthorcatfish-
dc.subject.keywordAuthorParasilurus asotus-
dc.subject.keywordPlusXENOPUS-LAEVIS-
dc.subject.keywordPlusSKIN-
dc.subject.keywordPlusDEFENSINS-
dc.subject.keywordPlusCELLS-
dc.subject.keywordPlusCDNA-
dc.subject.keywordPlusANTIBIOTICS-
dc.subject.keywordPlusLACTOFERRIN-
dc.subject.keywordPlusSECRETION-
dc.subject.keywordPlusMELITTIN-
dc.subject.keywordPlusFRAGMENT-
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