Angiopoietin-1 is an apoptosis survival factor for endothelial cells

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We examined the effect of angiopoietin-1 (Ang1) on apoptosis in human umbilical vein endothelial cells (HUVECs). Ang1 (5-1000 ng/ml) dose-dependently inhibited apoptosis under a serum-deprived state. A significant apoptotic inhibition occurred with as low as 50 ng/ml. Two hundred ng/ml of Ang1 inhibited to approximately 50% of the control apoptotic rates for 96 h. Furthermore, an augmented antiapoptotic effect of Ang1 by the addition of 20 ng/ml vascular endothelial growth factor was observed. This Ang1-iuduced strong antiapoptotic effect in endothelial cells is a novel and intriguing finding and could be an additional description of Ang1-induced direct biological function. (C) 1999 Federation of European Biochemical Societies.
Publisher
ELSEVIER SCIENCE BV
Issue Date
1999-04
Language
English
Article Type
Article
Keywords

GROWTH-FACTOR; TIE2 RECEPTOR; ANGIOGENESIS; EXPRESSION; INHIBITION; CYTOKINES; BIOLOGY; LIGAND; SYSTEM

Citation

FEBS LETTERS, v.448, no.2-3, pp.249 - 253

ISSN
0014-5793
DOI
10.1016/S0014-5793(99)00378-6
URI
http://hdl.handle.net/10203/77577
Appears in Collection
MSE-Journal Papers(저널논문)
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