DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Injune | ko |
dc.contributor.author | Koh, Gou Young | ko |
dc.contributor.author | Kim JH | ko |
dc.contributor.author | Ryu YS | ko |
dc.contributor.author | Liu M | ko |
dc.date.accessioned | 2013-03-03T06:09:20Z | - |
dc.date.available | 2013-03-03T06:09:20Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2000-03 | - |
dc.identifier.citation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.269, no.2, pp.361 - 365 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | http://hdl.handle.net/10203/77570 | - |
dc.description.abstract | The ansopoietin-Tie2 system is an important regulator of vasculogenesis and vascular integrity. Angiopoietin-2 (Ang2) disrupts blood vessel formation in the developing embryo by antagonizing the effects of angiopoietin-1 (Ang1) on the Tie2 receptor. In this study, we examined the effect of a well-known proinflammatory cytokine, tumor necrosis factor-alpha (TNF-alpha), on Ang2 expression in human umbilical vein endothelial cells. Reverse transcriptase-polymerase chain reaction and Northern blot analyses indicated that TNF-alpha induced Ang2 mRNA expression in a time- and dose-dependent manner. Western blot analyses revealed that TNF-alpha treatment increased cellular Ang2 protein. TNF-alpha-induced less Ang2 mRNA expression in the presence of nuclear factor-kappa B (NF-kappa B) inhibitor. These results suggest that TNF-alpha-induced inflammatory angiogenesis might be facilitated by the induction of Ang2. (C) 2000 Academic Press. | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC | - |
dc.subject | TIE2 RECEPTOR | - |
dc.subject | GROWTH-FACTOR | - |
dc.subject | ANGIOGENESIS | - |
dc.subject | LIGAND | - |
dc.subject | EXPRESSION | - |
dc.subject | KINASE | - |
dc.title | Tumor necrosis factor-alpha upregulates angiopoietin-2 in human umbilical vein endothelial cells. | - |
dc.type | Article | - |
dc.identifier.wosid | 000086023600012 | - |
dc.identifier.scopusid | 2-s2.0-0034673554 | - |
dc.type.rims | ART | - |
dc.citation.volume | 269 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 361 | - |
dc.citation.endingpage | 365 | - |
dc.citation.publicationname | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.identifier.doi | 10.1006/bbrc.2000.2296 | - |
dc.contributor.localauthor | Kim, Injune | - |
dc.contributor.localauthor | Koh, Gou Young | - |
dc.contributor.nonIdAuthor | Kim JH | - |
dc.contributor.nonIdAuthor | Ryu YS | - |
dc.contributor.nonIdAuthor | Liu M | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | TIE2 RECEPTOR | - |
dc.subject.keywordPlus | GROWTH-FACTOR | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | LIGAND | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | KINASE | - |
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