To improve the safety of plant start-up operation, a safety evaluation system has been developed. As a key component in an operational design support system, the evaluation system examines any potential hazards during start-up operation simulation. The evaluation system is integrated into an operational design methodology which designs operable processes by proposing alternatives, examining process safety and operability, and modifying operating procedures or plant structures. Issues for both methodology and implementation of a G2-based expert system are discussed. Finally, the system is applied to an industrial hydrodesulphurization process.