The large-scale organization of metabolic networks

Cited 3391 time in webofscience Cited 0 time in scopus
  • Hit : 931
  • Download : 0
In a cell or microorganism, the processes that generate mass, energy, information transfer and cell-fate specification are seamlessly integrated through a complex network of cellular constituents and reactions(1). However, despite the key role of these networks in sustaining cellular functions, their large-scale structure is essentially unknown. Here we present a systematic comparative mathematical analysis of the metabolic networks of 43 organisms representing all three domains of life. We show that, despite significant variation in their individual constituents and pathways, these metabolic networks have the same topological scaling properties and show striking similarities to the inherent organization of complex non-biological systems(2). This may indicate that metabolic organization is not only identical for all living organisms, but also complies with the design principles of robust and error-tolerant scale-free networks(2-5), and may represent a common blueprint for the large-scale organization of interactions among all cellular constituents.
Publisher
MACMILLAN PUBLISHERS LTD
Issue Date
2000-10
Language
English
Article Type
Article
Keywords

SMALL-WORLD NETWORKS

Citation

NATURE, v.407, no.6804, pp.651 - 654

ISSN
0028-0836
URI
http://hdl.handle.net/10203/75967
Appears in Collection
PH-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 3391 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0