DC Field | Value | Language |
---|---|---|
dc.contributor.author | Fiorillo, Christopher D. | ko |
dc.contributor.author | Williams, JT | ko |
dc.date.accessioned | 2013-03-02T20:43:39Z | - |
dc.date.available | 2013-03-02T20:43:39Z | - |
dc.date.created | 2012-03-19 | - |
dc.date.created | 2012-03-19 | - |
dc.date.issued | 1996-02 | - |
dc.identifier.citation | JOURNAL OF NEUROSCIENCE, v.16, no.4, pp.1479 - 1485 | - |
dc.identifier.issn | 0270-6474 | - |
dc.identifier.uri | http://hdl.handle.net/10203/75440 | - |
dc.description.abstract | In rat locus coeruleus (LC) neurons, alpha(2) adrenoceptors, mu-opioid and somatostatin receptors all activate the same potassium conductance. Chronic treatment with morphine causes a loss of sensitivity that is specific to the mu-opioid response, with no change in the alpha(2) adrenoceptor-mediated response. Acute desensitization induced by opioid, somatostatin, and alpha(2)-adrenoceptor agonists was studied in brain slices of rat LC using intracellular recording, A supramaximal concentration of the opioid agonist Met(5)-enkephalin induced a profound homologous desensitization but little heterologous desensitization to an alpha(2)-adrenoceptor agonist (UK 14304) or somatostatin, All desensitized currents showed partial recovery. A supramaximal concentration of UK14304 caused a relatively small amount of desensitization. Although little interaction was observed among inhibitory G-protein-coupled receptors, activation of an excitatory receptor had marked effects on inhibitory responses. Muscarinic agonists, which produce an inward current in LC neurons, reduced the magnitude of agonist-induced outward currents and increased both the rate and amount of opioid desensitization. Muscarinic activation did not alter desensitization of alpha(2)-adrenoceptor responses. Acute desensitization shares several characteristics with the tolerance induced by chronic morphine treatment of animals. | - |
dc.language | English | - |
dc.publisher | OXFORD UNIV PRESS INC | - |
dc.subject | BETA-GAMMA-SUBUNITS | - |
dc.subject | CHRONIC MORPHINE EXPOSURE | - |
dc.subject | NG108-15 HYBRID-CELLS | - |
dc.subject | ADENYLATE-CYCLASE | - |
dc.subject | CERULEUS NEURONS | - |
dc.subject | OPIATE | - |
dc.subject | BRAIN | - |
dc.subject | MECHANISMS | - |
dc.subject | ACTIVATION | - |
dc.subject | TOLERANCE | - |
dc.title | Opioid desensitization: Interactions with G-protein-coupled receptors in the locus coeruleus | - |
dc.type | Article | - |
dc.identifier.wosid | A1996TV54100020 | - |
dc.identifier.scopusid | 2-s2.0-0029865249 | - |
dc.type.rims | ART | - |
dc.citation.volume | 16 | - |
dc.citation.issue | 4 | - |
dc.citation.beginningpage | 1479 | - |
dc.citation.endingpage | 1485 | - |
dc.citation.publicationname | JOURNAL OF NEUROSCIENCE | - |
dc.contributor.localauthor | Fiorillo, Christopher D. | - |
dc.contributor.nonIdAuthor | Williams, JT | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | desensitization | - |
dc.subject.keywordAuthor | locus coeruleus | - |
dc.subject.keywordAuthor | brain slices | - |
dc.subject.keywordAuthor | mu-opioid | - |
dc.subject.keywordAuthor | alpha(2) adrenoceptor | - |
dc.subject.keywordAuthor | somatostatin | - |
dc.subject.keywordAuthor | muscarinic | - |
dc.subject.keywordPlus | BETA-GAMMA-SUBUNITS | - |
dc.subject.keywordPlus | CHRONIC MORPHINE EXPOSURE | - |
dc.subject.keywordPlus | NG108-15 HYBRID-CELLS | - |
dc.subject.keywordPlus | ADENYLATE-CYCLASE | - |
dc.subject.keywordPlus | CERULEUS NEURONS | - |
dc.subject.keywordPlus | OPIATE | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | TOLERANCE | - |
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