Antioxidants increase gene transfection efficiency of electroporation in B lymphoma cells

Abstract

Treatments of B lymphoma cells with dimethyl sulfoxide, nitric oxide, N-acetylcysteine, or pencillamine increased the gene transfection efficiency of electroporation (similar to 8-fold) without affecting cell viability. Decrease of electro-induced oxidative stress may explain antioxidant-increased electroporation efficiency.