DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, SJ | ko |
dc.contributor.author | Zhou, T | ko |
dc.contributor.author | Choi, Chulhee | ko |
dc.contributor.author | Wang, Z | ko |
dc.contributor.author | Benveniste, EN | ko |
dc.date.accessioned | 2013-03-02T17:45:15Z | - |
dc.date.available | 2013-03-02T17:45:15Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2000-02 | - |
dc.identifier.citation | JOURNAL OF IMMUNOLOGY, v.164, no.3, pp.1277 - 1285 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | http://hdl.handle.net/10203/74774 | - |
dc.description.abstract | Fas/Apo-1 is a member of the TNF receptor superfamily that signals apoptotic cell death in susceptible target cells. Fas or Fas ligand (FasL)-deficient mice are relatively resistant to the induction of experimental allergic encephalomyelitis, implying the involvement of Fas/FasL in this disease process. We have examined the regulation and function of Fas expression in glial cells (astrocytes and microglia), Fas is constitutively expressed by primary murine microglia at a low level and significantly upregulated by TNF-alpha or IFN-gamma stimulation. Primary astrocytes express high constitutive levels of Fas, which are not further affected by cytokine treatment. In microglia, Fas expression is regulated at the level of mRNA expression; TNF-alpha and IFN-gamma induced Fas mRNA by similar to 20-fold. STAT-1 alpha and NF-kappa B activation are involved in IFN-gamma- or TNF-alpha-mediated Fas up-regulation in microglia, respectively. The cytokine TGF-beta inhibits basal expression of Fas as well as cytokine-mediated Fas expression by microglia, Upon incubation of microglial cells with Fast-expressing cells, similar to 20% of cells underwent Fas-mediated cell death, which increased to similar to 60% when cells were pretreated with either TNF-alpha or IFN-gamma, TGF-beta treatment inhibited Fas-mediated cell death of TNF-alpha- or IFN-gamma-stimulated microglial cells. In contrast, astrocytes are resistant to Fas-mediated cell death, however, ligation of Fas induces expression of the chemokines macrophage inflammatory protein-1 beta (MIP-1 beta), MIP-1 alpha, and MIP-2. These data demonstrate that Fas transmits different signals in the two glial cell populations: a cytotoxic signal in microglia and an inflammatory signal in the astrocyte. | - |
dc.language | English | - |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | - |
dc.subject | CENTRAL-NERVOUS-SYSTEM | - |
dc.subject | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | - |
dc.subject | EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS | - |
dc.subject | TRANSFORMING GROWTH FACTOR-BETA-1 | - |
dc.subject | SIGNALING COMPLEX DISC | - |
dc.subject | T-CELLS | - |
dc.subject | INDUCED APOPTOSIS | - |
dc.subject | FACTOR-BETA | - |
dc.subject | MULTIPLE-SCLEROSIS | - |
dc.subject | PROTEIN-KINASE | - |
dc.title | Differential regulation and function of Fas expression on glial cells | - |
dc.type | Article | - |
dc.identifier.wosid | 000084910300019 | - |
dc.identifier.scopusid | 2-s2.0-0000146587 | - |
dc.type.rims | ART | - |
dc.citation.volume | 164 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 1277 | - |
dc.citation.endingpage | 1285 | - |
dc.citation.publicationname | JOURNAL OF IMMUNOLOGY | - |
dc.contributor.localauthor | Choi, Chulhee | - |
dc.contributor.nonIdAuthor | Lee, SJ | - |
dc.contributor.nonIdAuthor | Zhou, T | - |
dc.contributor.nonIdAuthor | Wang, Z | - |
dc.contributor.nonIdAuthor | Benveniste, EN | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | CENTRAL-NERVOUS-SYSTEM | - |
dc.subject.keywordPlus | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | - |
dc.subject.keywordPlus | EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS | - |
dc.subject.keywordPlus | TRANSFORMING GROWTH FACTOR-BETA-1 | - |
dc.subject.keywordPlus | SIGNALING COMPLEX DISC | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | FACTOR-BETA | - |
dc.subject.keywordPlus | MULTIPLE-SCLEROSIS | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
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