DC Field | Value | Language |
---|---|---|
dc.contributor.author | Byun, BH | ko |
dc.contributor.author | Shin, I | ko |
dc.contributor.author | Yoon, YS | ko |
dc.contributor.author | Kim, SI | ko |
dc.contributor.author | Joe, Cheol O | ko |
dc.date.accessioned | 2013-03-02T14:46:43Z | - |
dc.date.available | 2013-03-02T14:46:43Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 1997-10 | - |
dc.identifier.citation | PLANTA MEDICA, v.63, no.5, pp.389 - 392 | - |
dc.identifier.issn | 0032-0943 | - |
dc.identifier.uri | http://hdl.handle.net/10203/74038 | - |
dc.description.abstract | The involvement of ginsenosides in the signal cascade that stimulates cellular growth was investigated. It was found that ginsenosides Rh-1 and Rh-2 extracted from the root of Panax ginseng inhibited cellular proliferation in NIH 3T3 fibroblasts. Both ginsenosides Rh-1 and Rh-2 effectively reduced phospholipase C activity resulting in a decrease in the intracellular level of diacylglycerol, an endogenous activator of protein kinase C. The treatment of cells with Rh-1 or Rh-2 was thus found to reduce intracellular protein Itinase C activity. We also observed that the phosphorylation of myristoylated alanine-rich C kinase substrate, one of the major substrates of protein Itinase C in cells, was inhibited by the ginsenosides. Data suggest that the ginsenoside Rh-1 or Rh-2 exerts antiproliferative effects by inhibiting phospholipase C, which produces second messengers necessary for the activation of protein kinase C. | - |
dc.language | English | - |
dc.publisher | GEORG THIEME VERLAG | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | INHIBITION | - |
dc.subject | CALMODULIN | - |
dc.subject | SUBSTRATE | - |
dc.subject | METABOLISM | - |
dc.subject | INVITRO | - |
dc.subject | MARCKS | - |
dc.subject | PHOSPHATIDYLINOSITOL | - |
dc.subject | TRANSFORMATION | - |
dc.subject | INCREASES | - |
dc.title | Modulation of protein kinase C activity in NIH 313 cells by plant glycosides from Panax ginseng | - |
dc.type | Article | - |
dc.identifier.wosid | A1997XZ68900001 | - |
dc.identifier.scopusid | 2-s2.0-0030799814 | - |
dc.type.rims | ART | - |
dc.citation.volume | 63 | - |
dc.citation.issue | 5 | - |
dc.citation.beginningpage | 389 | - |
dc.citation.endingpage | 392 | - |
dc.citation.publicationname | PLANTA MEDICA | - |
dc.contributor.localauthor | Joe, Cheol O | - |
dc.contributor.nonIdAuthor | Byun, BH | - |
dc.contributor.nonIdAuthor | Shin, I | - |
dc.contributor.nonIdAuthor | Yoon, YS | - |
dc.contributor.nonIdAuthor | Kim, SI | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Panax ginseng | - |
dc.subject.keywordAuthor | araliaceae | - |
dc.subject.keywordAuthor | ginsenoside | - |
dc.subject.keywordAuthor | phospholipase C | - |
dc.subject.keywordAuthor | protein kinase C | - |
dc.subject.keywordAuthor | myristoylated alanine-rich C kinase substrate | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | CALMODULIN | - |
dc.subject.keywordPlus | SUBSTRATE | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | INVITRO | - |
dc.subject.keywordPlus | MARCKS | - |
dc.subject.keywordPlus | PHOSPHATIDYLINOSITOL | - |
dc.subject.keywordPlus | TRANSFORMATION | - |
dc.subject.keywordPlus | INCREASES | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.