Angiotensin-converting enzyme gene polymorphism in patients with minimal-change nephrotic syndrome and focal segmental glomerulosclerosis

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To evaluate angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism in nephrotic syndrome, 85 patients (minimal-change nephrotic syndrome, MCNS: 55 cases; focal segmental glomerulosclerosis, FSGS: 30 cases) and 61 control subjects were examined. The distribution of ACE genotype in the control group was II 44%, ID 41% and DD 15%. The distribution of ACE genotypes in MCNS was similar to that in controls. However, the distribution of ACE genotypes in FSGS was markedly different from those of MCNS. The DD genotype was more frequent (p < 0.05) in FSGS than in MCNS. Patients with the DD genotype tended to present clinical symptoms at an earlier age. They also showed a lower responsiveness to corticosteroid therapy and a higher incidence of chronic renal failure than those with other genotypes. Our results indicate that the ACE DD genotype in FSGS may be a risk factor for the poor responsiveness to steroid therapy and the development of chronic renal failure.
Publisher
KARGER
Issue Date
1997-12
Language
English
Article Type
Article
Keywords

IGA NEPHROPATHY; DELETION POLYMORPHISM; DIABETIC NEPHROPATHY; PROGRESSION; CARDIOMYOPATHY; GENOTYPE; CELLS

Citation

NEPHRON, v.77, pp.471 - 473

ISSN
0028-2766
URI
http://hdl.handle.net/10203/73851
Appears in Collection
MSE-Journal Papers(저널논문)
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