DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee M. | ko |
dc.contributor.author | Yang, Kyu Hwan | ko |
dc.contributor.author | Kim H. M. | ko |
dc.date.accessioned | 2013-02-28T05:26:25Z | - |
dc.date.available | 2013-02-28T05:26:25Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 1996-03 | - |
dc.identifier.citation | CANCER LETTERS, v.101, no.1, pp.53 - 57 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.uri | http://hdl.handle.net/10203/72998 | - |
dc.description.abstract | Z-Acetylaminofluorene (AAF), an arylamide carcinogen, inhibited in a dose dependent manner mouse spleen cell prolif eration in response to lipopolysaccharide (LPS). The objective of the present studies was to investigate the effects of AAF on protein kinase C (PKC) activation, an enzyme required for LPS-induced splenocytes proliferation. After treatment with 50 mu M AAF for 18 h, PKC activity in the cytosolic fraction decreased by 50% from the control level, and splenocytes lost 30% of total PKC activity. Furthermore, as determined by the electrophoretic mobility shift assay, AAF inhibited the binding activity of the transcription factor complex, NF-kappa B, whose LPS-mediated induction is dependent on PKC activation in murine splenocytes. These results strongly suggest that LPS-mediated signaling in spleen cells is interrupted by AAF early in the signal transduction pathway, at a point proximal to the activation of PKC. | - |
dc.language | English | - |
dc.publisher | Elsevier Ireland Ltd | - |
dc.subject | RAT HEPATOCYTES | - |
dc.subject | ACTIVATION | - |
dc.title | Down regulation of protein kinase C in murine splenocytes: a potential mechanism of 2-acetylaminofluorene mediated immunosuppression | - |
dc.type | Article | - |
dc.identifier.wosid | A1996TW79700009 | - |
dc.identifier.scopusid | 2-s2.0-0030059603 | - |
dc.type.rims | ART | - |
dc.citation.volume | 101 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 53 | - |
dc.citation.endingpage | 57 | - |
dc.citation.publicationname | CANCER LETTERS | - |
dc.contributor.nonIdAuthor | Lee M. | - |
dc.contributor.nonIdAuthor | Kim H. M. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | 2-acetylaminofluorene | - |
dc.subject.keywordAuthor | immunosuppression | - |
dc.subject.keywordAuthor | protein kinase C | - |
dc.subject.keywordPlus | RAT HEPATOCYTES | - |
dc.subject.keywordPlus | ACTIVATION | - |
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