DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ju, Bong-Gun | ko |
dc.contributor.author | Bae, Eunkyung | ko |
dc.contributor.author | Jeong, Sangyun | ko |
dc.contributor.author | Hyun, Seogang | ko |
dc.contributor.author | Carroll, Sean B. | ko |
dc.contributor.author | Yim, Jeongbin | ko |
dc.contributor.author | Kim, Jaeseob | ko |
dc.date.accessioned | 2013-02-28T03:04:33Z | - |
dc.date.available | 2013-02-28T03:04:33Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2000-01 | - |
dc.identifier.citation | NATURE, v.405, no.1, pp.191 - 195 | - |
dc.identifier.issn | 0028-0836 | - |
dc.identifier.uri | http://hdl.handle.net/10203/72440 | - |
dc.description.abstract | The Fringe protein of Drosophila and its vertebrate homologues function in boundary determination during pattern formation(1-9). Fringe has been proposed to inhibit Serrate-Notch signalling but to potentiate Delta-Notch signalling(10). Here we show that Fringe and Notch form a complex through both the Lin-Notch repeats and the epidermal growth factor repeats 22-36 (EGF22-36) of Notch when they are co-expressed. The Abruptex(59b) (Ax(59b)) and Ax(M1) mutations, which are caused by missense mutations in EGF repeats 24 and 25, respectively, abolish the Fringe-Notch interaction through EGF22-36, whereas the l(1)N-B mutation in the third Lin-Notch repeat of Notch abolishes the interaction through Lin-Notch repeats. Ax mutations also greatly affect the Notch response to ectopic Fringe in vivo. Results from in vitro protein mixing experiments and subcellular colocalization experiments indicate that the Fringe-Notch complex may form before their secretion. These findings explain how Fringe acts cell-autonomously to modulate the ligand preference of Notch and why the Fringe-Notch relationship is conserved between phyla and in the development of very diverse structures. | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.subject | DROSOPHILA WING DEVELOPMENT | - |
dc.subject | DORSAL-VENTRAL BOUNDARY | - |
dc.subject | DORSOVENTRAL BOUNDARY | - |
dc.subject | SIGNAL-TRANSDUCTION | - |
dc.subject | EXPRESSION | - |
dc.subject | ACTIVATION | - |
dc.subject | RECEPTOR | - |
dc.subject | SERRATE | - |
dc.subject | GROWTH | - |
dc.subject | DELTA | - |
dc.title | Fringe forms a complex with Notch | - |
dc.type | Article | - |
dc.identifier.wosid | 000087080100053 | - |
dc.identifier.scopusid | 2-s2.0-0034636541 | - |
dc.type.rims | ART | - |
dc.citation.volume | 405 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 191 | - |
dc.citation.endingpage | 195 | - |
dc.citation.publicationname | NATURE | - |
dc.identifier.doi | 10.1038/35012090 | - |
dc.contributor.localauthor | Kim, Jaeseob | - |
dc.contributor.nonIdAuthor | Ju, Bong-Gun | - |
dc.contributor.nonIdAuthor | Bae, Eunkyung | - |
dc.contributor.nonIdAuthor | Jeong, Sangyun | - |
dc.contributor.nonIdAuthor | Hyun, Seogang | - |
dc.contributor.nonIdAuthor | Carroll, Sean B. | - |
dc.contributor.nonIdAuthor | Yim, Jeongbin | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | DROSOPHILA WING DEVELOPMENT | - |
dc.subject.keywordPlus | DORSAL-VENTRAL BOUNDARY | - |
dc.subject.keywordPlus | DORSOVENTRAL BOUNDARY | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | SERRATE | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | DELTA | - |
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