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College of Natural Sciences(자연과학대학)Dept. of Chemistry(화학과)CH-Journal Papers(저널논문)

Design and synthesis of N-alkylated saccharins as selective alpha-1A adrenergic receptor antagonists

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dc.contributor.authorNerenberg, JBko
dc.contributor.authorErb, JMko
dc.contributor.authorThompson, WJko
dc.contributor.authorLee, Hee Yoonko
dc.contributor.authorGuare, JPko
dc.contributor.authorMunson, PMko
dc.contributor.authorBergman, JMko
dc.contributor.authorHuff, JRko
dc.contributor.authorBroten, TPko
dc.contributor.authorChang, RSLko
dc.contributor.authorChen, TBko
dc.contributor.authorO'Malley, Sko
dc.contributor.authorSchorn, TWko
dc.contributor.authorScott, ALko
dc.date.accessioned2013-02-27T23:46:18Z-
dc.date.available2013-02-27T23:46:18Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued1998-09-
dc.identifier.citationBIOORGANIC MEDICINAL CHEMISTRY LETTERS, v.8, no.18, pp.2467 - 2472-
dc.identifier.issn0960-894X-
dc.identifier.urihttp://hdl.handle.net/10203/71556-
dc.description.abstractBenign prostatic hyperplasia can be managed pharmacologically with alpha-1 adrenergic receptor antagonists. Agents that demonstrate selectivity for the alpha-1a receptor subtype may offer advantages in clinical applications with respect to hypotensive side effects. The N-alkylated saccharins reported here represent a new class of subtype selective alpha-1a adrenergic receptor antagonists which demonstrate potent effects on prostate function in vivo and are devoid of blood pressure side effects. (C) 1998 Elsevier Science Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectBENIGN PROSTATIC HYPERPLASIA-
dc.subjectALPHA(1C)-
dc.subjectEFFICACY-
dc.subjectSAFETY-
dc.titleDesign and synthesis of N-alkylated saccharins as selective alpha-1A adrenergic receptor antagonists-
dc.typeArticle-
dc.identifier.wosid000076271200012-
dc.identifier.scopusid2-s2.0-16744364284-
dc.type.rimsART-
dc.citation.volume8-
dc.citation.issue18-
dc.citation.beginningpage2467-
dc.citation.endingpage2472-
dc.citation.publicationnameBIOORGANIC MEDICINAL CHEMISTRY LETTERS-
dc.identifier.doi10.1016/S0960-894X(98)00446-6-
dc.contributor.localauthorLee, Hee Yoon-
dc.contributor.nonIdAuthorNerenberg, JB-
dc.contributor.nonIdAuthorErb, JM-
dc.contributor.nonIdAuthorThompson, WJ-
dc.contributor.nonIdAuthorGuare, JP-
dc.contributor.nonIdAuthorMunson, PM-
dc.contributor.nonIdAuthorBergman, JM-
dc.contributor.nonIdAuthorHuff, JR-
dc.contributor.nonIdAuthorBroten, TP-
dc.contributor.nonIdAuthorChang, RSL-
dc.contributor.nonIdAuthorChen, TB-
dc.contributor.nonIdAuthorO'Malley, S-
dc.contributor.nonIdAuthorSchorn, TW-
dc.contributor.nonIdAuthorScott, AL-
dc.type.journalArticleArticle; Proceedings Paper-
dc.subject.keywordPlusBENIGN PROSTATIC HYPERPLASIA-
dc.subject.keywordPlusALPHA(1C)-
dc.subject.keywordPlusEFFICACY-
dc.subject.keywordPlusSAFETY-
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