DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, Y | ko |
dc.contributor.author | Gil, M | ko |
dc.contributor.author | Byun, Si Myung | ko |
dc.contributor.author | Choi, I | ko |
dc.contributor.author | Pyun, KH | ko |
dc.contributor.author | Ha, HJ | ko |
dc.date.accessioned | 2013-02-27T18:54:35Z | - |
dc.date.available | 2013-02-27T18:54:35Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 1996-11 | - |
dc.identifier.citation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.228, no.3, pp.807 - 812 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | http://hdl.handle.net/10203/70225 | - |
dc.description.abstract | We studied regulation of a receptor-type tyrosine phosphatase R-PTP-kappa gene expression in a human keratinocyte cell line, HaCaT. Addition of TGF-beta 1 to the HaCaT cells markedly induced the expression of R-PTP-kappa mRNA in a time- and dose-dependent manner. The induction of R-PTP-kappa mRNA expression was observed at a dose as low as 0.02 ng/ml TGF-beta 1 and reached a peak at 2 ng/ml TGF-beta 1 after 6 h treatment. The TGF-beta 1-induced R-PTP-kappa mRNA expression was suppressed by sodium orthovanadate, a tyrosine phosphatase inhibitor, and H7, a serine/threonine kinase inhibitor, but not by genistein, a tyrosine kinase inhibitor. In addition, the inducing effect is not dependent on de novo protein synthesis. Taken together, these results suggest that TGF-beta 1 inhibits the human keratinocyte proliferation in vitro, possibly through induction of R-PTP-kappa gene expression. (C) 1996 Academic Press, Inc. | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS | - |
dc.subject | FACTOR-BETA | - |
dc.subject | REVERSIBLE INHIBITION | - |
dc.subject | CELL PROLIFERATION | - |
dc.subject | COLLAGEN | - |
dc.subject | STIMULATION | - |
dc.subject | FIBRONECTIN | - |
dc.subject | FIBROBLASTS | - |
dc.subject | SUPPRESSION | - |
dc.subject | INDUCTION | - |
dc.subject | INVIVO | - |
dc.title | Transforming growth factor-beta 1 inhibits human keratinocyte proliferation by upregulation of a receptor-type tyrosine phosphatase R-PTP-kappa gene expression | - |
dc.type | Article | - |
dc.identifier.wosid | A1996VV00200024 | - |
dc.type.rims | ART | - |
dc.citation.volume | 228 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 807 | - |
dc.citation.endingpage | 812 | - |
dc.citation.publicationname | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.identifier.doi | 10.1006/bbrc.1996.1736 | - |
dc.contributor.nonIdAuthor | Yang, Y | - |
dc.contributor.nonIdAuthor | Gil, M | - |
dc.contributor.nonIdAuthor | Choi, I | - |
dc.contributor.nonIdAuthor | Pyun, KH | - |
dc.contributor.nonIdAuthor | Ha, HJ | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
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