DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ahn, SC | ko |
dc.contributor.author | Kim, BY | ko |
dc.contributor.author | Park, CS | ko |
dc.contributor.author | Lee, HS | ko |
dc.contributor.author | Suh, PG | ko |
dc.contributor.author | Ryu, SH | ko |
dc.contributor.author | Rho, HM | ko |
dc.contributor.author | Rhee, Joon Shick | ko |
dc.contributor.author | Mheen, TI | ko |
dc.contributor.author | Ahn, JS | ko |
dc.date.accessioned | 2013-02-27T17:39:41Z | - |
dc.date.available | 2013-02-27T17:39:41Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 1995-09 | - |
dc.identifier.citation | BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL, v.37, no.1, pp.125 - 132 | - |
dc.identifier.issn | 1039-9712 | - |
dc.identifier.uri | http://hdl.handle.net/10203/69889 | - |
dc.description.abstract | In the search for a substance which would specifically block a particular step in the signal transduction cascade, we identified glucopiericidin A produced by Streptomyces sp, as an inhibitor of phosphoinositide (PI)-turnover in phospholipase-C gamma 1 (PLC-gamma 1) overexpressing NM 3T3 fibroblasts (NIH 3T3 gamma 1). Glucopiericidin A inhibited the formation of inositol phosphate (IPt) in platelet-derived growth factor (PDGF)-stimulated NIH 3T3 gamma 1 cells with an IC50 of 5.0 mu M, In vitro enzyme assay showed the compound had no inhibitory effect on PLC-gamma 1 even at 100 mu M concentration. Glucopiericidin A reduced PDGF-induced tyrosine phosphorylations of proteins, including PDGF receptor and PLC-gamma 1, in the cells. In contrast, glucopiericidin A showed only a slight inhibitory effect on epidermal growth factor (EGF)- (EGF)-induced IPt production and protein tyrosine phosphorylations in A431 cells. These results suggest that glucopiericidin A inhibits PDGF-induced activation of PLC-gamma 1 by reducing the tyrosine kinase activity of the PDGF receptor and it more potently inhibits PI-turnover induced by PDGF than by EGF. | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS AUST | - |
dc.title | Inhibition of PDGF-induced phosphoinositide-turnover by glucopiericidin A | - |
dc.type | Article | - |
dc.identifier.wosid | A1995VG87200016 | - |
dc.identifier.scopusid | 2-s2.0-0029550651 | - |
dc.type.rims | ART | - |
dc.citation.volume | 37 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 125 | - |
dc.citation.endingpage | 132 | - |
dc.citation.publicationname | BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL | - |
dc.contributor.nonIdAuthor | Ahn, SC | - |
dc.contributor.nonIdAuthor | Kim, BY | - |
dc.contributor.nonIdAuthor | Park, CS | - |
dc.contributor.nonIdAuthor | Lee, HS | - |
dc.contributor.nonIdAuthor | Suh, PG | - |
dc.contributor.nonIdAuthor | Ryu, SH | - |
dc.contributor.nonIdAuthor | Rho, HM | - |
dc.contributor.nonIdAuthor | Mheen, TI | - |
dc.contributor.nonIdAuthor | Ahn, JS | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | EGF | - |
dc.subject.keywordAuthor | Glucopiericidin A | - |
dc.subject.keywordAuthor | PDGF | - |
dc.subject.keywordAuthor | Phosphoinositide-turnover | - |
dc.subject.keywordAuthor | Phospholipase Cγ1 | - |
dc.subject.keywordPlus | PHOSPHOLIPASE-C-GAMMA | - |
dc.subject.keywordPlus | 2ND MESSENGERS | - |
dc.subject.keywordPlus | GROWTH-FACTOR | - |
dc.subject.keywordPlus | MITOGENESIS | - |
dc.subject.keywordPlus | ANTIBODIES | - |
dc.subject.keywordPlus | SUBSTRATE | - |
dc.subject.keywordPlus | C-GAMMA-1 | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | CELLS | - |
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