DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, SY | ko |
dc.contributor.author | Chung, Jae Hoon | ko |
dc.contributor.author | Kang, Kae Won | ko |
dc.contributor.author | Joe, Cheol O | ko |
dc.contributor.author | Park, KH | ko |
dc.date.accessioned | 2013-02-27T07:48:36Z | - |
dc.date.available | 2013-02-27T07:48:36Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 1992-01 | - |
dc.identifier.citation | DRUG AND CHEMICAL TOXICOLOGY, v.15, no.4, pp.313 - 327 | - |
dc.identifier.issn | 0148-0545 | - |
dc.identifier.uri | http://hdl.handle.net/10203/67322 | - |
dc.description.abstract | Benzo(a)pyrene metabolism in human placental microsomes from smokers was studied. Benzo(a)pyrene metabolites were separated using high pressure liquid chromatographic technique. Reaction of benzo(a)pyrene with a microsomal fraction of placenta from individuals who smoke cigarettes during pregnency yields 7,8 dihydroxy benzo(a)pyrene as a major metabolite, while 3'-hydroxy benzo(a)pyrene, 4,5 dihydroxy benzo(a)pyrene and quinones constitute minor metabolites. The activities of arylhydrocarbon hydroxylase and 7-ethoxycoumarine deethylase exhibited much higher activities in smokers than in nonsmokers. Examination of specific binding of monoclonal antibodies to cytochrome P-450 isozymes in placental microsomes revealed that cigaratte smoking specifically enhanced the level of cytochrome P-450 c and d isozymes in human placental microsomes. Coincubation of H-3-benzo(a)pyrene and calf thymus DNA with placental microsomes yielded acid insoluble H-3-B(a)P from smokers, suggesting that cigarette smoking may induce placental enzymes which convert benzo(a)pyrene into ultimate metabolites to form carcinogen-DNA adducts. | - |
dc.language | English | - |
dc.publisher | Informa Healthcare | - |
dc.subject | HUMAN-LYMPHOCYTES | - |
dc.subject | ENZYME-ACTIVITY | - |
dc.subject | HYDROCARBONS | - |
dc.subject | INDUCTION | - |
dc.subject | LIVER | - |
dc.subject | CARCINOGENESIS | - |
dc.subject | HYDROXYLASE | - |
dc.subject | ACTIVATION | - |
dc.subject | PRODUCTS | - |
dc.subject | CELLS | - |
dc.title | Relationship between activities of cytochrome P-450 monooxygenases in human placental microsomes and binding of benzo(a)pyrene metabolites to calf thymus DNA | - |
dc.type | Article | - |
dc.identifier.wosid | A1992JY76200004 | - |
dc.identifier.scopusid | 2-s2.0-0026483243 | - |
dc.type.rims | ART | - |
dc.citation.volume | 15 | - |
dc.citation.issue | 4 | - |
dc.citation.beginningpage | 313 | - |
dc.citation.endingpage | 327 | - |
dc.citation.publicationname | DRUG AND CHEMICAL TOXICOLOGY | - |
dc.contributor.localauthor | Chung, Jae Hoon | - |
dc.contributor.localauthor | Joe, Cheol O | - |
dc.contributor.nonIdAuthor | Kim, SY | - |
dc.contributor.nonIdAuthor | Park, KH | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | HUMAN-LYMPHOCYTES | - |
dc.subject.keywordPlus | ENZYME-ACTIVITY | - |
dc.subject.keywordPlus | HYDROCARBONS | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | LIVER | - |
dc.subject.keywordPlus | CARCINOGENESIS | - |
dc.subject.keywordPlus | HYDROXYLASE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PRODUCTS | - |
dc.subject.keywordPlus | CELLS | - |
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