Increased Shikonin Production by Hairy Roots of Lithospermum erythrorhizon in Two Phase Bubble Column Reactor

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Plant hairy root cultures of Lithospermum erythrorhizon were carried out to produce shikonin derivatives by employing in situ extraction with n-hexadecane in a shake flask and a bubble column bioreactor. Over 95 % shikonin produced was recovered in the n-hexadecane layer. In flask cultures the maximum concentration of shikonin with n-hexadecane extraction was 3 times higher than that obtained without extraction. In the two phase bubble column reactor, 572.6 mg/L of shikonin and 15.6 g/L of dry cell mass were obtained after 54 days. Shikonin was produced at a constant level of 10.6 mg/L.day during this period.
Publisher
Springer
Issue Date
1993
Language
English
Article Type
Article
Keywords

CULTURES; GROWTH

Citation

BIOTECHNOLOGY LETTERS, v.15, no.2, pp.145 - 150

ISSN
0141-5492
URI
http://hdl.handle.net/10203/60305
Appears in Collection
CBE-Journal Papers(저널논문)
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