Showing results 1 to 40 of 40
A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1 Wang, Yingfei; An, Ran; Umanah, George K.; Park, Hyejin; Nambiar, Kalyani; Eacker, Stephen M.; Kim, BongWoo; et al, SCIENCE, v.354, no.6308, 2016-10 |
alpha-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism![]() Yun, Seung Pil; Kim, Donghoon; Kim, Sangjune; Kim, SangMin; Karuppagounder, Senthilkumar S.; Kwon, Seung-Hwan; Lee, Saebom; et al, MOLECULAR NEURODEGENERATION, v.13, 2018-01 |
Amelioration of amyloid -FcRIIb neurotoxicity and tau pathologies by targeting LYN Gwon, Youngdae; Kim, Seo-Hyun; Kim, Hyun Tae; Kam, Tae-In; Park, Jisu; Lim, Bitna; Cha, Hyunju; et al, FASEB JOURNAL, v.33, no.3, pp.4300 - 4313, 2019-03 |
Amelioration of pathologic alpha-synuclein-induced Parkinson's disease by irisin![]() Kam, Tae-In; Park, Hyejin; Chou, Shih-Ching; Van Vranken, Jonathan G.; Mittenbuhler, Melanie J.; Kim, Hyeonwoo; Mu, A.; et al, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.119, no.36, 2022-09 |
Amyloid beta receptors responsible for neurotoxicity and cellular defects in Alzheimer's disease Kam, Tae-In; Gwon, Youngdae; Jung, Yong-Keun, CELLULAR AND MOLECULAR LIFE SCIENCES, v.71, no.24, pp.4803 - 4813, 2014-12 |
BECN1/Beclin 1 is recruited into lipid rafts by prion to activate autophagy in response to amyloid beta 42 Nah, Jihoon; Pyo, Jong-Ok; Jung, Sunmin; Yoo, Seung-Min; Kam, Tae-In; Chang, JaeWoong; Han, Jonghee; et al, AUTOPHAGY, v.9, no.12, pp.2009 - 2021, 2013-12 |
Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease Yun, Seung Pil; Kam, Tae-In; Panicker, Nikhil; Kim, SangMin; Oh, Yumin; Park, Jong-Sung; Kwon, Seung-Hwan; et al, NATURE MEDICINE, v.24, no.7, pp.931 - +, 2018-07 |
Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer's disease Park, Jong-Sung; Kam, Tae-In; Lee, Saebom; Park, Hyejin; Oh, Yumin; Kwon, Seung-Hwan; Song, Jae-Jin; et al, ACTA NEUROPATHOLOGICA COMMUNICATIONS, v.9, no.1, 2021-04 |
Caspase-cleaved tau exhibits rapid memory impairment associated with tau oligomers in a transgenic mouse model Kim, YoungDoo; Choi, Hyunwoo; Lee, WonJae; Park, Hyejin; Kam, Tae-In; Hong, Se-Hoon; Nah, Jihoon; et al, NEUROBIOLOGY OF DISEASE, v.87, pp.19 - 28, 2016-03 |
Complement and Coagulation Cascades are Potentially Involved in Dopaminergic Neurodegeneration in alpha-Synuclein-Based Mouse Models of Parkinson's Disease Ma, Shi-Xun; Seo, Bo Am; Kim, Donghoon; Xiong, Yulan; Kwon, Seung-Hwan; Brahmachari, Saurav; Kim, Sangjune; et al, JOURNAL OF PROTEOME RESEARCH, v.20, no.7, pp.3428 - 3443, 2021-07 |
Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity Xu, Jin-Chong; Fan, Jing; Wang, Xueqing; Eacker, Stephen M.; Kam, Tae-In; Chen, Li; Yin, Xiling; et al, SCIENCE TRANSLATIONAL MEDICINE, v.8, no.333, 2016-04 |
E2-25K/Hip-2 regulates caspase-12 in ER stress-mediated A beta neurotoxicity Song, Sungmin; Lee, Huikyong; Kam, Tae-In; Tai, Mei Ling; Lee, Joo-Yong; Noh, Jee-Yeon; Shim, Sang Mi; et al, JOURNAL OF CELL BIOLOGY, v.182, no.4, pp.675 - 684, 2008-08 |
Essential role of POLDIP2 in Tau aggregation and neurotoxicity via autophagy/proteasome inhibition Kim, YoungDoo; Park, Hyejin; Nah, Jihoon; Moon, Seowon; Lee, WonJae; Hong, Se-hoon; Kam, Tae-In; et al, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.462, no.2, pp.112 - 118, 2015-06 |
Fc gamma RIIb mediates amyloid-beta neurotoxicity and memory impairment in Alzheimer's disease Kam, Tae-In; Song, Sungmin; Gwon, Youngdae; Park, Hyejin; Yan, Ji-Jing; Im, Isak; Choi, Ji-Woo; et al, JOURNAL OF CLINICAL INVESTIGATION, v.123, no.7, pp.2791 - 2802, 2013-07 |
Fc gamma RIIb-SHIP2 axis links A beta to tau pathology by disrupting phosphoinositide metabolism in Alzheimer's disease mode Kam, Tae-In; Park, Hyejin; Gwon, Youngdae; Song, Sungmin; Kim, Seo-Hyun; Moon, Seo Won; Jo, Dong-Gyu; et al, ELIFE, v.5, 2016-11 |
Fyn kinase regulates misfolded alpha-synuclein uptake and NLRP3 inflammasome activation in microglia Panicker, Nikhil; Sarkar, Souvarish; Harischandra, Dilshan S.; Neal, Matthew; Kam, Tae-In; Jin, Huajun; Saminathan, Hariharan; et al, JOURNAL OF EXPERIMENTAL MEDICINE, v.216, no.6, pp.1411 - 1430, 2019-06 |
Glial pathology and retinal neurotoxicity in the anterior visual pathway in experimental autoimmune encephalomyelitis![]() Jin, Jing; Smith, Matthew D.; Kersbergen, Calvin J.; Kam, Tae-In; Viswanathan, Mayuri; Martin, Kyle; Dawson, Ted M.; et al, ACTA NEUROPATHOLOGICA COMMUNICATIONS, v.7, 2019-07 |
Interleukin-6 triggers toxic neuronal iron sequestration in response to pathological alpha-synuclein Sterling, Jacob K.; Kam, Tae-In; Guttha, Samyuktha; Park, Hyejin; Baumann, Bailey; A.Mehrabani-Tabari, Amir; Schultz, Hannah; et al, CELL REPORTS, v.38, no.7, 2022-02 |
Large-scale phenotypic drug screen identifies neuroprotectants in zebrafish and mouse models of retinitis pigmentosa Zhang, Liyun; Chen, Conan; Fu, Jie; Lilley, Brendan; Berlinicke, Cynthia; Hansen, Baranda; Ding, Ding; et al, ELIFE, v.10, 2021-06 |
Lysosomal Enzyme Glucocerebrosidase Protects against A beta(1-42) Oligomer-Induced Neurotoxicity Choi, Seulah; Kim, Donghoon; Kam, Tae-In; Yun, Seungpil; Kim, Sangjune; Park, Hyejin; Hwang, Heehong; et al, PLOS ONE, v.10, no.12, 2015-12 |
MEK1/2 inhibition rescues neurodegeneration by TFEB-mediated activation of autophagic lysosomal function in a model of Alzheimer's Disease![]() Chun, Yoon Sun; Kim, Mi-Yeon; Lee, Sun-Young; Kim, Mi Jeong; Hong, Tae-Joon; Jeon, Jae Kyong; Ganbat, Dulguun; et al, MOLECULAR PSYCHIATRY, v.27, no.11, pp.4770 - 4780, 2022-11 |
Microglia and astrocyte dysfunction in parkinson's disease![]() Kam, Tae-In; Hinkle, Jared T.; Dawson, Ted M.; Dawson, Valina L., NEUROBIOLOGY OF DISEASE, v.144, 2020-10 |
Neuropathogenic role of adenylate kinase-1 in A-mediated tau phosphorylation via AMPK and GSK3 Park, Hyejin; Kam, Tae-In; Kim, Youngdoo; Choi, Hyunwoo; Gwon, Youngdae; Kim, Changsoo; Koh, Jae-Young; et al, HUMAN MOLECULAR GENETICS, v.21, no.12, pp.2725 - 2737, 2012-06 |
OCIAD2 activates gamma-secretase to enhance amyloid beta production by interacting with nicastrin Han, Jonghee; Jung, Sunmin; Jang, Jiyeon; Kam, Tae-In; Choi, Hyunwoo; Kim, Byung-Ju; Nah, Jihoon; et al, CELLULAR AND MOLECULAR LIFE SCIENCES, v.71, no.13, pp.2561 - 2576, 2014-07 |
Overexpression of Atg5 in mice activates autophagy and extends lifespan![]() Pyo, Jong-Ok; Yoo, Seung-Min; Ahn, Hye-Hyun; Nah, Jihoon; Hong, Se-Hoon; Kam, Tae-In; Jung, Sunmin; et al, NATURE COMMUNICATIONS, v.4, 2013-08 |
PAAN/MIF nuclease inhibition prevents neurodegeneration in Parkinson's disease Park, Hyejin; Kam, Tae-In; Peng, Hanjing; Chou, Shih-Ching; Mehrabani-Tabari, Amir A.; Song, Jae-Jin; Yin, Xiling; et al, CELL, v.185, no.11, pp.1943 - 1959, 2022-05 |
PAR-kinson’s Disease? ; Role of Poly (ADP-ribose) (PAR) in Neurodegenerative Diseases Kam, Tae-In, Neurodegeneration: New Biology Guiding the Next Generation of Therapeutic Development, Keystone Symposia on Molecular and Cellular Biology, 2023-05-17 |
PARIS farnesylation prevents neurodegeneration in models of Parkinson's disease Jo, Areum; Lee, Yunjong; Kam, Tae-In; Kang, Sung-Ung; Neifert, Stewart; Karuppagounder, Senthilkumar S.; Khang, Rin; et al, SCIENCE TRANSLATIONAL MEDICINE, v.13, no.604, 2021-07 |
PARIS undergoes liquid-liquid phase separation and poly(ADP-ribose)-mediated solidification Kang, Hojin; Park, Soojeong; Jo, Areum; Mao, Xiaobo; Kumar, Manoj; Park, Chi-Hu; Ahn, Jee-Yin; et al, EMBO REPORTS, v.24, no.11, 2023-11 |
Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson's disease Brahmachari, Saurav; Lee, Saebom; Kim, Sangjune; Yuan, Changqing; Karuppagounder, Senthilkumar S.; Ge, Preston; Shi, Rosa; et al, BRAIN, v.142, pp.2380 - 2401, 2019-08 |
Pathogenic Role of RAGE in Tau Transmission and Memory Deficits Kim, Youbin; Park, Hyejin; Kim, Youngwon; Kim, Seo-Hyun; Lee, Jae Hoon; Yang, Hanseul; Kim, Seo Jin; et al, BIOLOGICAL PSYCHIATRY, v.93, no.9, pp.829 - 841, 2023-05 |
Pathological alpha-synuclein transmission initiated by binding lymphocyte-activation gene 3 Mao, Xiaobo; Ou, Michael Tianhao; Karuppagounder, Senthilkumar S.; Kam, Tae-In; Yin, Xiling; Xiong, Yulan; Ge, Preston; et al, SCIENCE, v.353, no.6307, 2016-09 |
PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival![]() Lee, Yunjong; Stevens, Daniel A.; Kang, Sung-Ung; Jiang, Haisong; Lee, Yun-Il; Ko, Han Seok; Scarffe, Leslie A.; et al, CELL REPORTS, v.18, no.4, pp.918 - 932, 2017-01 |
Poly (ADP-ribose) (PAR)-dependent cell death in neurodegenerative diseases Park, Hyejin; Kam, Tae-In; Dawson, Ted M.; Dawson, Valina L., CELL DEATH REGULATION IN HEALTH AND DISEASE - PT C, v.353, pp.1 - 29, 2020 |
Poly(ADP-ribose) drives pathologic alpha-synuclein neurodegeneration in Parkinson's disease Kam, Tae-In; Mao, Xiaobo; Park, Hyejin; Chou, Shih-Ching; Karuppagounder, Senthilkumar S.; Umanah, George Essien; Yun, Seung Pil; et al, SCIENCE, v.362, no.6414, 2018-11 |
Reactive astrocyte-derived neurotoxins are responsible for the neurodegeneration in a model of Parkinson’s disease Kam, Tae-In, Neuroscience 2023, Society for Neuroscience, 2023-11-13 |
Recent advances in preventing neurodegenerative diseases Chou, Shih-Ching; Aggarwal, Akanksha; Dawson, Valina L.; Dawson, Ted M.; Kam, Tae-In, Faculty Reviews, v.10, 2021 |
TOM1 Regulates Neuronal Accumulation of Amyloid-beta Oligomers by Fc gamma RIIb2 Variant in Alzheimer's Disease Gwon, Youngdae; Kam, Tae-In; Kim, Seo-Hyun; Song, Sungmin; Park, Hyejin; Lim, Bitna; Lee, Haneul; et al, JOURNAL OF NEUROSCIENCE, v.38, no.42, pp.9001 - 9018, 2018-10 |
Transneuronal Propagation of Pathologic alpha-Synuclein from the Gut to the Brain Models Parkinson's Disease Kim, Sangjune; Kwon, Seung-Hwan; Kam, Tae-In; Panicker, Nikhil; Karuppagounder, Senthilkumar S.; Lee, Saebom; Lee, Jun Hee; et al, NEURON, v.103, no.4, pp.627 - 641, 2019-08 |
TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson's disease Seo, Bo Am; Kim, Donghoon; Hwang, Heehong; Kim, Min Seong; Ma, Shi-Xun; Kwon, Seung-Hwan; Kweon, Sin Ho; et al, NEURON, v.109, no.23, pp.3758 - 3774, 2021-12 |
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