Research for existence of bone marrow-derived circulating preadipocytes and therapeutic vasculogenesis using adipose stromal vascular fraction-derived endothelial cells = 골수유래 지방전구세포의 탐색과 지방조직내 혈관내피세포를 이용한 치료적 혈관신생 연구

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Fat tissues mainly regulate metabolism and reproduction. Adipocytes generate throughout life, with the massive expansion occurring during the postnatal period. Recently, adipose stromal vascular fraction (SVF)-derived white adipocyte progenitor cells are indentified, but the identity of bone marrow-derived white and brown adipocyte progenitor cells in vivo are unknown. Moreover, adipose SVF is not only containing adipocyte progenitors, but also a mixture of blood endothelial cells, immune cells, fibroblasts, pericytes, stromal cells and yet undefined stem/progenitor cells. Previous studies have shown that mesenchymal stem/progenitor cells in SVF can be cultured to successfully differentiate into adipocytes, pericytes, osteoblasts, chondrocytes and myocytes under optimized condi-tions. However, little is known about freshly isolated donor adipose SVF can readily provide blood endothelial cells to create a vascular network through a ‘disassembly and reassembly’ mechanism. Hence, we attempt to describe the existence of bone marrow-derived circulating adipose progenitor cells, and the cellular events occurring in the process of vascular network formation from freshly isolated adipose SVF as a source candidate for cell therapy and suggest their potential therapeutic applications. Here, I divided this thesis into two chapters as follow: bone marrow-derived circulating progenitor cells fail to transdifferntiate into adipocytes in adult adipose tissues in mice (part I), and freshly isolated stromal vascular fraction from adipose tissue forms profound vascular network through the disassembly and reassembly of blood endothelial cells in mice (part II). Part I. Abstract Little is known about whether bone-marrow-derived circulating progenitor cells (BMDCPCs) can transdifferentiate into adipocytes in adipose tissues and play a specific role in expanding adipocyte number in adipose tissue growth. Using a mouse bone marrow transplantation model and a parabiosis model...
Koh, Gou-Youngresearcher고규영researcher
한국과학기술원 : 의과학대학원,
Issue Date
466431/325007  / 020068044

학위논문(박사) - 한국과학기술원 : 의과학대학원, 2011.2, [ viii, 108 p. ]


bone marrow-derived circulating progenitor cell; stromal vascular fraction; adipocyte; adipose tissue; blood endothelial cell; 혈관내피세포; 골수유래 전구세포; 지방조직내 기질세포; 지방세포; 지방조직

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