Highly diastereoselective additions of methoxyallene and acetylenes to chiral alpha-keto amides
alpha -Keto amides bearing (S)-indoline chiral auxiliaries reacted with lithiated methoxyallene or lithium acetylides to produce the corresponding dihydrofuranones 7 through formation of the tertiary alpha -hydroxy allenes, or tertiary alpha -hydroxy acetylenes, respectively, at -78 degreesC with high diastereoselectivities (up to > 99% de).
- Publisher
- ROYAL SOC CHEMISTRY
- Issue Date
- 2001
- Language
- English
- Article Type
- Article
- Keywords
TERTIARY HOMOALLYL ALCOHOLS; ASYMMETRIC-SYNTHESIS; STEREOSELECTIVE SYNTHESIS; ENANTIOSELECTIVE ALKYNYLATION; LITHIATED METHOXYALLENE; LEWIS-ACIDS; ALDEHYDES; ESTERS; 3(2H)-DIHYDROFURANONES; ALKOXYALLENES
- Citation
CHEMICAL COMMUNICATIONS, pp.996 - 997
- ISSN
- 1359-7345
- Appears in Collection
- CH-Journal Papers(저널논문)
- Files in This Item
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