How astrocytes regulate microglia in CNS injury: BST2-high astrocytes at the border

Abstract

In this issue of Neuron, Zhang et al. identified a subset of BST2-high astrocytes that emerge at the ischemic injury border and promote microglial recruitment through the C3-C3aR pathway. These findings highlight BST2 as a key modulator of astrocyte-microglia communication and a potential therapeutic target for CNS injury.