(The) synthesis of small molecule library using diagonal combinatorial chemistry대각선형 조합화학을 이용한 저분자 라이브러리 합성 ;

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dc.contributor.advisorLee, Hee-Yoon-
dc.contributor.advisor이희윤-
dc.contributor.authorShin, Jeong-Joo-
dc.contributor.author신정주-
dc.date.accessioned2011-12-13T05:01:09Z-
dc.date.available2011-12-13T05:01:09Z-
dc.date.issued1997-
dc.identifier.urihttp://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=112771&flag=dissertation-
dc.identifier.urihttp://hdl.handle.net/10203/32751-
dc.description학위논문(석사) - 한국과학기술원 : 화학과, 1997.2, [ [iv], 81 p. ]-
dc.description.abstractRecent trends in search for novel pharmaceutical agents have focused on the preparation of small molecule libraries as potential sources of new lead compounds for drug discovery. Several powerful chemical and biological techniques have been developed for this purpose. This thesis presents an advanced method of constructing combinatorial library, which was demonstrated by generating twenty-fivecompounds through reductive amination with a set of five aldehyde derivatives and a set of five secondary amines. It was presented as three sets of subraries in which each of the reagent cumulatively reacted with the corresponding substrates as normal-diagonal,reversed-diagonal and crossed-diagonalmethods in order to deduced the most active compound exactly and efficiently. This diagonal library could provide intrinsic effectiveness that had never been favored in the orthogonal or indexed library known. The diagonal library was designed to have four approaching directions within the matrix, while conventional techniques had only two approaching directions. Thereby, we could improve the possibility of finding true active compound discovery because they had intrinsically acquired additional checking means. As a result, we could reduce the inexactness that associated with surveying true lead compound from libraries.eng
dc.languageeng-
dc.publisher한국과학기술원-
dc.subjectAntagonist-
dc.subjectIndexed-
dc.subjectDiagonal-
dc.subjectCombinatorial chemistry-
dc.subjectReceptor-
dc.subject수용체-
dc.subject길항제-
dc.subject좌표-
dc.subject대각선형-
dc.subject조합화학-
dc.title(The) synthesis of small molecule library using diagonal combinatorial chemistry-
dc.title.alternative대각선형 조합화학을 이용한 저분자 라이브러리 합성 ;-
dc.typeThesis(Master)-
dc.identifier.CNRN112771/325007-
dc.description.department한국과학기술원 : 화학과, -
dc.identifier.uid000943300-
dc.contributor.localauthorLee, Hee-Yoon-
dc.contributor.localauthor이희윤-
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CH-Theses_Master(석사논문)
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