DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Kang, Sung-Ho | - |
dc.contributor.advisor | 강성호 | - |
dc.contributor.author | Yoo, Yong-Sang | - |
dc.contributor.author | 유용상 | - |
dc.date.accessioned | 2011-12-13T05:00:30Z | - |
dc.date.available | 2011-12-13T05:00:30Z | - |
dc.date.issued | 1995 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=98752&flag=dissertation | - |
dc.identifier.uri | http://hdl.handle.net/10203/32708 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 화학과, 1995.2, [ ii, 59 p. ] | - |
dc.description.abstract | We have investigated a new synthetic voute to (+)-retronecine and its analogs, which exhibit various pharmacological and biological activities. Stereoselective iodoamination of allylic imidate was employed as a key step for their syntheses. Iodocyclization of allylic imidate of 68 was carried out using iodine as electrophile to furnish oxazoline 71. The strategy applied to allylic alcohol 68 was unsuccessful due to poor stereo-selectivity of the iodocyclization and the failure to secure the bicyclic pyrrolizidine. Iodocyclization of allylic imidates from 93 and 95 with iodine mono-bromide showed excellent stereoselectivities to yield trans-oxazolines 96 and 97 exclusively. A synthesis of bicyclic pyrrolizidine skeleton 157 was attempted in overall 9 steps from osazoline 96. | eng |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.title | Synthetic approaches to (+)-retronecine | - |
dc.title.alternative | (+)- 리트로넥신의 합성에 관한 연구 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 98752/325007 | - |
dc.description.department | 한국과학기술원 : 화학과, | - |
dc.identifier.uid | 000933315 | - |
dc.contributor.localauthor | Kang, Sung-Ho | - |
dc.contributor.localauthor | 강성호 | - |
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