DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Kim, Yong-Hae | - |
dc.contributor.advisor | 김용해 | - |
dc.contributor.author | Cha, Tae-Woon | - |
dc.contributor.author | 차태운 | - |
dc.date.accessioned | 2011-12-13T05:00:05Z | - |
dc.date.available | 2011-12-13T05:00:05Z | - |
dc.date.issued | 1994 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=69194&flag=dissertation | - |
dc.identifier.uri | http://hdl.handle.net/10203/32681 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 화학과, 1994.2, [ v, 50 p. ] | - |
dc.description.abstract | During the study on the biologically active compounds from Ligia Exotica a novel inosine derivative was isolated and then purified by HPLC on GS 320 and ODS column. It was expected to be 3``-O-Glucosyl inosine on the basis of various spectroscopic analysis. The novel inosine derivative was synthesized by the coupling of benzylated glucosyl trichloroimidate with $^1N$-Benzyl-5``-O-acetyl inosine in the presence of $BF_3OEt_2$. But this synthetic route exposed some problems such as low chemical yield, and poor regio-, stereoselectivity. In an effort to circumvent these shortcomings new synthetic access has been developed. For the preparation of selective glycosyl acceptor t-Butyldimethyl silyl(TBDMS) protecting group was introduced to inosine. Then, the glycosylation of a O-(2,3,4,6-tetra-O-benzyl-α-glucosyl) trichloroimidate to a $^1N$-Benzyl-2``,5``-di-O-TBDMS inosine gave satisfactory result in the aspects of chemical yield and regio-,stereo- selectivity of a required α isomer. ◁그림 삽입▷(원문을 참조하세요) | eng |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.title | Synthesis of a novel inosine derivative from ligia exotica | - |
dc.title.alternative | 갯강구로부터 추출된 새로운 이노신 유도체의 합성 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 69194/325007 | - |
dc.description.department | 한국과학기술원 : 화학과, | - |
dc.identifier.uid | 000923513 | - |
dc.contributor.localauthor | Kim, Yong-Hae | - |
dc.contributor.localauthor | 김용해 | - |
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