(A) study of selective complexation phenomena among macromolecules by qualitative and quantitative methods정성적 방법과 정량적 방법을 이용한 고분자 상호간의 선택적 복합체 형성에 관한 연구
In chapter 1, intermacromolecular complex formations between poly(L-proline) (PLP) having $\alpha$ -helical conformation and complementary macromolecules, such as poly (methacrylic acid)(PMAA) and poly(acrylic acid)(PAA) having random-coiled conformation, through hydrogen bonding in aqueous medium have been studied by viscosity measurement. And selective intermacromolecular complexation phenomea in ternary-component system involving macromolecules with different conformations, such as poly(L-proline)(PLP), poly(ethylene oxide)(PEO), and poly(methacrylic acid)(PMAA) has been studied by viscosity measurement. From the reduced viscosity change for the binary-component systems, the minimum points at [PLP]/[PMAA]=1.0 and [PLP]/[PAA]=1.0 suggest 1:1 complex formation, and for the ternary-component system it may be suggested that relative complexation ability of a helical PLP is greater than that of a random-coiled PEO with respective to a random-coiled PMAA. In chapter 2, stability constants and thermodynamic parameters of (i.e. standard free energy change $F^\circ$, standard enthalpy change $H^\circ$, and standard entropy change $\triangle{S}^\circ$) have been determined for intermacromolecular complexation processes in binary-component systems composed of PLP, PVPo, PEO, PMAA, and PAA. Comparing these values in binary-component systems the selectivity of a particular macromolecule in multicomponent systems with respective to a complementary macromolecule was calculated. From these results it has been observed that the complexation ability is determined by the conformation of participating macro-molecules as well as the interacting strength of active sites.